Evidence map›Paper›PMID 37905065›Full record

ArticlebioRxiv : the preprint server for biology2023

Divergent changes in PBN excitability in a mouse model of neuropathic pain.

María L Torruella-Suárez, Benjamin Neugebauer, Krystal Flores-Felix, Asaf Keller, Yarimar Carrasquillo, Nathan Cramer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

María L Torruella-SuárezNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland.
Benjamin NeugebauerNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland.
Krystal Flores-FelixDepartment of Neurobiology and UM-MIND, University of Maryland School of Medicine, Baltimore, Maryland.
Asaf KellerDepartment of Neurobiology and UM-MIND, University of Maryland School of Medicine, Baltimore, Maryland.
Yarimar CarrasquilloNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland.
Nathan CramerDepartment of Neurobiology and UM-MIND, University of Maryland School of Medicine, Baltimore, Maryland.
National Institutes of Health · USUniversity of Maryland, Baltimore · US

Funding

Parabrachial role in chronic painR01NS099245 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KELLER, ASAF, MASRI, RADI · 2017 to 2021
$2.2M
Motor Cortex Stimulation Reverses Maladaptive Plasticity Following Spinal InjuryR01NS069568 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI MASRI, RADI · 2010 to 2014
$1.4M
NINDS NIH HHS R01 NS069568NINDS NIH HHS R01 NS099245
6 · The paper itself

Abstract

The transition from acute to chronic pain involves maladaptive plasticity in central nociceptive pathways. Growing evidence suggests that changes within the parabrachial nucleus (PBN), an important component of the spino-parabrachio-amygdaloid pain pathway, are key contributors to the development and maintenance of chronic pain. In animal models of chronic pain, PBN neurons become sensitive to normally innocuous stimuli and responses to noxious stimuli become amplified and more often produce after-discharges that outlast the stimulus. Using

Identifiers

PMID37905065
PMCPMC10614750
OpenAlexW4387666701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.