Evidence map›Paper›PMID 37905056›Full record

ArticlebioRxiv : the preprint server for biology2024

Commissureless acts as a substrate adapter in a conserved Nedd4 E3 ubiquitin ligase pathway to promote axon growth across the midline.

Kelly G Sullivan, Greg J Bashaw

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kelly G SullivanDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd., Philadelphia, PA, 19104, USA.
Greg J BashawDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd., Philadelphia, PA, 19104, USA.ORCID 0000-0002-6146-0962
University of Pennsylvania · US

Funding

TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0M
Molecular mechanisms of axon guidance receptor regulation and signalingR35NS097340 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASHAW, GREG J. · 2017 to 2024
$5.8M
Regulation of axon guidance receptor trafficking in the developing mammalian central nervous systemR01HD105946 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BASHAW, GREG J. · 2021 to 2025
$2.3M
The Role of Intracellular Trafficking in Regulating Axon Guidance Receptors During Neuronal Circuit FormationF31NS115345 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SULLIVAN, KELLY GALE · 2019 to 2022
$125k
NICHD NIH HHS R01 HD105946NIGMS NIH HHS T32 GM007229NINDS NIH HHS F31 NS115345NINDS NIH HHS R35 NS097340
6 · The paper itself

Abstract

In both vertebrates and invertebrates, commissural neurons prevent premature responsiveness to the midline repellant Slit by downregulating surface levels of its receptor Roundabout1 (Robo1). In

Indexed as

Axon guidanceCommissurelessE3 Ubiquitin ligaselysosomal degradationmidlineNdfipNedd4Slit-Robo

Identifiers

PMID37905056
PMCPMC10614773
OpenAlexW4387693889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.