Evidence map›Paper›PMID 37905049›Full record

ArticlebioRxiv : the preprint server for biology2023

Development of covalent chemogenetic K

Parker E Deal, Haerim Lee, Abhisek Mondal, Marco Lolicato, Philipe Ribeiro Furtado de Mendonca, Holly Black, Xochina El-Hilali, Clifford Bryant, Ehud Y Isacoff, Adam R Renslo and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Parker E DealCardiovascular Research Institute, University of California, San Francisco, California 93858-2330 USA.
Haerim LeeCardiovascular Research Institute, University of California, San Francisco, California 93858-2330 USA.
Abhisek MondalCardiovascular Research Institute, University of California, San Francisco, California 93858-2330 USA.
Marco LolicatoCardiovascular Research Institute, University of California, San Francisco, California 93858-2330 USA.
Philipe Ribeiro Furtado de MendoncaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, United States.
Holly BlackDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, United States.
Xochina El-HilaliDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 93858-2330 USA.
Clifford BryantDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 93858-2330 USA.
Ehud Y IsacoffDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, United States.
Adam R RensloDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 93858-2330 USA.
Daniel L MinorCardiovascular Research Institute, University of California, San Francisco, California 93858-2330 USA.

Funding

MOLECULAR AND CELLULAR BASIS OF CARDIOVASCULAR DISEASET32HL007731 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 1992 to 2026
$12.4M
Genetic and chemical biological studies of K2P structure, function, andmodulationR01MH093603 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL L MINOR · 2011 to 2026
$8.5M
Conformational mechanisms of mGluR gating and regulationR01NS119826 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2021 to 2024
$1.6M
Synaptic to circuit homeostasis in the Drosophila locomotor systemR01NS107506 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2019 to 2023
$1.6M
Expanding the Chemical Biology of K2P Channels with Selective Cellular and In vivo ProbesR01MH116278 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MINOR, DANIEL L, RENSLO, ADAM R · 2018 to 2020
$1.4M
Voltage Gating MechanismsR01GM117051 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2016 to 2019
$1.3M
NHLBI NIH HHS T32 HL007731NIGMS NIH HHS R01 GM117051NIMH NIH HHS R01 MH093603NIMH NIH HHS R01 MH116278NINDS NIH HHS R01 NS107506NINDS NIH HHS R01 NS119826
6 · The paper itself

Abstract

K

Indexed as

chemogeneticselectrophysiologyK2P channelX-ray crystallography

Identifiers

PMID37905049
PMCPMC10614804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.