Evidence map›Paper›PMID 37905026›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Identification and development of Tetra-ARMS PCR-based screening test for a genetic variant of OLA1 (Tyr254Cys) in the human failing heart.

Praveen K Dubey, Shubham Dubey, Sarojini Singh, Purnima Devaki Bhat, Steven Pogwizd, Prasanna Krishnamurthy

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Praveen K DubeyDepartment of Biomedical Engineering, Schools of Medicine and Engineering, University of Alabama at Birmingham, AL, USA.
Shubham DubeyDepartment of Biomedical Engineering, Schools of Medicine and Engineering, University of Alabama at Birmingham, AL, USA.
Sarojini SinghDepartment of Biomedical Engineering, Schools of Medicine and Engineering, University of Alabama at Birmingham, AL, USA.
Purnima Devaki BhatDepartment of Biomedical Engineering, Schools of Medicine and Engineering, University of Alabama at Birmingham, AL, USA.
Steven PogwizdComprehensive Cardiovascular Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Prasanna KrishnamurthyDepartment of Biomedical Engineering, Schools of Medicine and Engineering, University of Alabama at Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

Mesenchymal Stem Cell Exosome in Efferocytosis of Apoptotic Cardiomyocytes and Repair after Myocardial IschemiaR01HL138023 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KRISHNAMURTHY, PRASANNA, ZHANG, JIANYI · 2018 to 2021
$2.6M
microRNA mediation of Endothelial Progenitor Cell function in Myocardial IchemiaR01HL116729 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KRISHNAMURTHY, PRASANNA · 2013 to 2017
$1.9M
NHLBI NIH HHS R01 HL116729NHLBI NIH HHS R01 HL138023
6 · The paper itself

Abstract

Obg-like ATPase 1 (OLA1) protein has GTP and ATP hydrolyzing activities and is important for cellular growth and survival. The human OLA1 gene maps on chromosome 2, at the locus 1q31, close to the Titin (TTN) gene, which is associated with familial dilated cardiomyopathy (DCM). In this study, we found that expression of OLA1 was significantly downregulated in human failing heart tissue (HF) as compared to in non-failing heart tissues (NF). Moreover, using the Sanger sequencing method, we characterized the human OLA1 gene and screened genetic mutations in patients with heart-failing and non-failing. Among failing and non-failing heart patients, we found a total of 15 mutations, including two transversions, one substitution, one indel, and eleven transition mutations in the

Indexed as

Genetic screeningHeart failureMutationObg-like ATPase 1 (OLA1)Tetra ARMS-PCR

Identifiers

PMID37905026
PMCPMC10615000
OpenAlexW4387770353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.