Evidence map›Paper›PMID 37904969›Full record

ArticlebioRxiv : the preprint server for biology2023

The genetic evolution of acral melanoma.

Meng Wang, Satoshi Fukushima, Yi-Shuan Sheen, Egle Ramelyte, Noel Cruz Pacheco, Chenxu Shi, Shanshan Liu, Ishani Banik, Jamie D Aquino, Martin Sangueza Acosta and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 5 countries.

Meng WangDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Satoshi FukushimaDepartment of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Yi-Shuan SheenDepartment of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Egle RamelyteDepartment of Dermatology, University of Zurich, Zurich, Switzerland.
Noel Cruz PachecoDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Chenxu ShiDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Shanshan LiuDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Ishani BanikDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Jamie D AquinoDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Martin Sangueza AcostaHospital Obrero, Caja Nacional de Salud, La Paz, Bolivia.
Mitchell LevesqueDepartment of Dermatology, University of Zurich, Zurich, Switzerland.
Reinhard DummerDepartment of Dermatology, University of Zurich, Zurich, Switzerland.
Jau-Yu LiauDepartment of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Chia-Yu ChuDepartment of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
A Hunter ShainDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Iwei YehDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Boris C BastianDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USJoint Graduate School of Energy and Environment · THNational Taiwan University Hospital · TWUniversity of Zurich · CHKumamoto University · JP

Funding

Molecular and immunologic evolution of melanomas from pre-neoplastic lesionsR35CA220481 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASTIAN, BORIS C. · 2017 to 2023
$6.3M
The genomic landscape and evolution of cutaneous squamous cell carcinomaR01CA265786 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Hunter Shain · 2022 to 2026
$2.1M
The mutational mechanisms shaping melanocytes in human skinR01AR080626 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Hunter Shain · 2023 to 2026
$1.6M
NCI NIH HHS R01 CA265786NCI NIH HHS R35 CA220481NIAMS NIH HHS R01 AR080626
6 · The paper itself

Abstract

Acral melanoma is an aggressive type of melanoma with unknown origins, arising on the sole, palm, or nail apparatus. It is the most common type of melanoma in individuals with dark skin and is notoriously challenging to treat. Our study examined exome sequencing data from 139 tissue samples, spanning different progression stages, collected from 37 patients. We found that 78.4% of the melanomas displayed one or more clustered copy number transitions with focal amplifications, recurring predominantly on chromosomes 5, 11, 12, and 22. These genomic "hailstorms" were typically shared across all progression stages within individual patients. Genetic alterations known to activate

Identifiers

PMID37904969
PMCPMC10614839
OpenAlexW4387819878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.