Evidence map›Paper›PMID 37904959›Full record

ArticlebioRxiv : the preprint server for biology2023

OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records.

Qingwen Chen, Varun B Dwaraka, Natàlia Carreras-Gallo, Kevin Mendez, Yulu Chen, Sofina Begum, Priyadarshini Kachroo, Nicole Prince, Hannah Went, Tavis Mendez and 15 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. DNA methylation and prediction of biological age.Frontiers in molecular biosciences · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 5 institutions in 3 countries.

Qingwen ChenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Varun B DwarakaTruDiagnostic, Inc., Lexington, KY USA.
Natàlia Carreras-GalloTruDiagnostic, Inc., Lexington, KY USA.
Kevin MendezChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Yulu ChenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sofina BegumChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Priyadarshini KachrooChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Nicole PrinceChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Hannah WentTruDiagnostic, Inc., Lexington, KY USA.
Tavis MendezTruDiagnostic, Inc., Lexington, KY USA.
Aaron LinTruDiagnostic, Inc., Lexington, KY USA.
Logan TurnerTruDiagnostic, Inc., Lexington, KY USA.
Mahdi MoqriDivision of Genetics, Dept. of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Su H ChuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Rachel S KellyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Nicholas J W RattrayStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Vadim N GladyshevDivision of Genetics, Dept. of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Elizabeth KarlsonDepartment of Personalized Medicine, Mass General Brigham and Harvard Medical School, Boston, MA, USA.
Craig WheelockDivision of Physiological Chemistry 2, Dept of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Ewy A MathéDivision of Preclinical Innovation, National Center for Advancing Translational Science, National Institutes of Health, Rockville, MD, USA.
Amber DahlinChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Michae J McGeachieChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ryan SmithTruDiagnostic, Inc., Lexington, KY USA.
Jessica A Lasky-SuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USHarvard University · USKarolinska Institutet · SENational Institutes of Health · USUniversity of Strathclyde · GB

Funding

Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
Informatics Research CoreZICTR000410 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI MATHÉ, EWY · 2021 to 2025
$11.7M
Integrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0M
Pharmacogenomics of Adrenal Suppression with Inhaled Corticosteroids (PhASIC)R01HL152244 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DAHLIN, AMBER · 2020 to 2024
$4.4M
Asthma Exacerbations and MicroRNA prediction: Treatment Response in an Underserved Ethnicity (AEM-TRUE)R01HL139634 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MCGEACHIE, MICHAEL JOHN · 2018 to 2022
$4.3M
QUANTITATIVE ASSESSMENT OF BIOLOGICAL AGE AND ITS APPLICATIONSR01AG065403 · NIA · YALE UNIVERSITY · PI Vadim N. Gladyshev, Albert Tzongyang Higgins-Chen · 2020 to 2026
$4.2M
Omic Determinants of Longitudinal Lung Function in AsthmaR01HL155742 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A, MCGEACHIE, MICHAEL JOHN · 2021 to 2025
$3.9M
Mechanistic insights into asthma pathogenesis through the integration of asthma genes, risk exposures, and metabolomicsR01HL141826 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2018 to 2021
$3.4M
Role of rare damaging mutations in agingR01AG064223 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2020 to 2024
$2.8M
Better utilization of omics data to inform precision medicine for asthma throughout the life courseR01HL169300 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI JESSICA A LASKY-SU · 2024 to 2026
$2.3M
Multi-Omic Endotyping of AsthmaK01HL146980 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KELLY, RACHEL SABINE · 2019 to 2023
$891k
Integrative metabolomic characterization of ADHD and asthma comorbidityK01HL153941 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHU, SU HEE · 2020 to 2024
$891k
Intramural NIH HHS ZIC TR000410Medical Research Council MR/Y010736/1NHGRI NIH HHS U01 HG008685NHLBI NIH HHS K01 HL130629NHLBI NIH HHS K01 HL146980NHLBI NIH HHS K01 HL153941NHLBI NIH HHS K99 HL159234NHLBI NIH HHS R01 HL123915NHLBI NIH HHS R01 HL139634NHLBI NIH HHS R01 HL141826NHLBI NIH HHS R01 HL152244NHLBI NIH HHS R01 HL155742NHLBI NIH HHS R01 HL169300NIA NIH HHS R01 AG064223NIA NIH HHS R01 AG065403
6 · The paper itself

Abstract

Biological aging is a multifactorial process involving complex interactions of cellular and biochemical processes that is reflected in omic profiles. Using common clinical laboratory measures in ~30,000 individuals from the MGB-Biobank, we developed a robust, predictive biological aging phenotype,

Indexed as

agingbiobankbiological agingclockepigeneticsmetabolomicsmulti-omicsproteomics

Identifiers

PMID37904959
PMCPMC10614756
OpenAlexW4387809061

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.