Evidence map›Paper›PMID 37904946›Full record

ArticlebioRxiv : the preprint server for biology2025

Comparative analyses of disease-linked missense mutations in the RNA exosome modeled in budding yeast reveal distinct functional consequences in translation.

Maria C Sterrett, Lauryn A Cureton, Lauren N Cohen, Ambro van Hoof, Sohail Khoshnevis, Milo B Fasken, Anita H Corbett, Homa Ghalei

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria C SterrettDepartment of Biology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-9772-2426
Lauryn A CuretonGenetics and Molecular Biology Graduate Program, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-4098-1777
Lauren N CohenDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Ambro van HoofDepartment of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-7800-9764
Sohail KhoshnevisDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-7607-2041
Milo B FaskenDepartment of Biology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0003-4317-7909
Anita H CorbettDepartment of Biology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-0461-6895
Homa GhaleiDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-0168-4654
Emory University · USThe University of Texas Health Science Center at Houston · US

Funding

Biogenesis of macromolecular machines for post-transcriptional regulation of translationR35GM138123 · NIGMS · EMORY UNIVERSITY · PI Homa Ghalei · 2020 to 2026
$3.0M
Training Program in Biochemistry, Cell and Molecular BiologyT32GM135060 · NIGMS · EMORY UNIVERSITY · PI Lawrence H. Boise, ANITA H. CORBETT · 2020 to 2026
$2.8M
RNAse functions in post-transcriptional gene regulationR35GM141710 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VAN HOOF, AMBRO · 2021 to 2025
$2.4M
Genetics Predoctoral Training ProgramT32GM149422 · NIGMS · EMORY UNIVERSITY · PI TAMARA J. CASPARY · 2023 to 2026
$2.2M
Insight Into The RNA Processing And Decay Pathways Critical For Proper Neuronal Development And Function Through Focus On Mutations That Cause Pontocerebellar HypoplasiaR01GM130147 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CORBETT, ANITA H., VAN HOOF, AMBRO · 2018 to 2021
$1.4M
A Budding Yeast Model for Human Disease-Mutations in the RNA ExosomeF31GM134649 · NIGMS · EMORY UNIVERSITY · PI STERRETT, MARIA CARSON · 2020 to 2022
$138k
The role of rRNA modifications in regulation of translation initiationF31GM157874 · NIGMS · EMORY UNIVERSITY · PI Lauryn Cureton · 2025 to 2026
$99k
NIGMS NIH HHS F31 GM134649NIGMS NIH HHS F31 GM157874NIGMS NIH HHS R01 GM130147NIGMS NIH HHS R35 GM138123NIGMS NIH HHS R35 GM141710NIGMS NIH HHS T32 GM135060NIGMS NIH HHS T32 GM149422
6 · The paper itself

Abstract

The RNA exosome is a multi-subunit, evolutionarily conserved ribonuclease complex that is essential for processing, decay and surveillance of many cellular RNAs. Missense mutations in genes encoding the structural subunits of the RNA exosome complex cause a diverse range of diseases, collectively known as RNA exosomopathies, often involving neurological and developmental defects. The varied symptoms suggest that different mutations lead to distinct

Indexed as

budding yeast disease modelRNA exosomeRNA exosomopathytranslation dysregulation

Identifiers

PMID37904946
PMCPMC10614903
OpenAlexW4387771381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.