Evidence map›Paper›PMID 37904936›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Regional quantification of cardiac metabolism with hyperpolarized [1-

Peder E Z Larson, Shuyu Tang, Xiaoxi Liu, Avantika Sinha, Nicholas Dwork, Sanjay Sivalokanathan, Jing Liu, Robert Bok, Karen G Ordovas, James Slater and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
Shuyu TangDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
Xiaoxi LiuDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
Avantika SinhaDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
Nicholas DworkDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
Sanjay SivalokanathanDepartment of Medicine - Division of Internal Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jing LiuDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
Robert BokDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
Karen G OrdovasDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
James SlaterDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
M Roselle AbrahamDepartment of Medicine - Cardiology Division, University of California - San Francisco, San Francisco, California, USA.
University of California, San Francisco · USPalo Alto University · USUniversity of Pennsylvania · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Preclinical imaging characterization and resource development of PDX SCNC prostate cancer murine modelsU24CA253377 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, PEEHL, DONNA M. · 2020 to 2024
$3.4M
Hyperpolarized Carbon-13 Metabolic MRI of the Human HeartR33HL161816 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAHAM, MARIA ROSELLE, LARSON, PEDER ERIC ZUFALL · 2022 to 2023
$965k
NCI NIH HHS U24 CA253377NHLBI NIH HHS R33 HL161816NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

Background: The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) Methods: We developed and applied methods for whole-heart imaging of Results: We demonstrate whole heart coverage for dynamic measurement of pyruvate-to-lactate conversion via LDH and pyruvate-to-bicarbonate conversion via PDH at a resolution of 6×6×21 mm Conclusions: We demonstrate first-in-human regional quantifications of cardiac metabolism by HP

Identifiers

PMID37904936
PMCPMC10615005
OpenAlexW4387770345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.