ArticleMagnetic resonance (Gottingen, Germany)2021
A novel sample handling system for dissolution dynamic nuclear polarization experiments.
Article in Magnetic resonance (Gottingen, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Unmasking DNA Resonances by Suppression of Hyperpolarized Water.Journal of the American Chemical Society · 2026Article
- Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA.Journal of the American Chemical Society · 2025Article
- Hyperpolarized NMR Combined with Quantum Mechanical Simulations Reveal Atomistic Structures of Calcium Phosphate Prenucleation Clusters.Analytical chemistry · 2025Article
- Short-lived calcium carbonate precursors observed in situ via Bullet-dynamic nuclear polarization.Communications chemistry · 2024Article
- Biphasic NMR of Hyperpolarized Suspensions-Real-Time Monitoring of Solute-to-Solid Conversion to Watch Materials Grow.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023Article
- Introduction to "Geoffrey Bodenhausen Festschrift".Magnetic resonance (Gottingen, Germany) · 2023Article
- Frémy's Salt as a Low-Persistence Hyperpolarization Agent: Efficient Dynamic Nuclear Polarization Plus Rapid Radical Scavenging.Journal of the American Chemical Society · 2022Article
- Nuclear Overhauser spectroscopy in hyperpolarized water - chemicalChemical communications (Cambridge, England) · 2022Article
- Toward protein NMR at physiological concentrations by hyperpolarized water-Finding and mapping uncharted conformational spaces.Science advances · 2022Article
- Hyperpolarized water as universal sensitivity booster in biomolecular NMR.Nature protocols · 2022Review
- Inversion of HyperpolarizedThe journal of physical chemistry. B · 2022Article
- Fine optimization of a dissolution dynamic nuclear polarization experimental setting forMagnetic resonance (Gottingen, Germany) · 2022Article
- A cryogen-free, semi-automated apparatus for bullet-dynamic nuclear polarization with improved resolution.Magnetic resonance (Gottingen, Germany) · 2021Article
- A novel sample handling system for dissolution dynamic nuclear polarization experiments.Magnetic resonance (Gottingen, Germany) · 2021Article
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Authors and funding
8 authors.
Funding
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Abstract
We present a system for facilitated sample vitrification, melting, and transfer in dissolution dynamic nuclear polarization (DDNP) experiments. In DDNP, a sample is typically hyperpolarized at cryogenic temperatures before dissolution with hot solvent and transfer to a nuclear magnetic resonance (NMR) spectrometer for detection in the liquid state. The resulting signal enhancements can exceed 4 orders of magnitude. However, the sudden temperature jump from cryogenic temperatures close to 1 K to ambient conditions imposes a particular challenge. It is necessary to rapidly melt the sample to avoid a prohibitively fast decay of hyperpolarization. Here, we demonstrate a sample dissolution method that facilitates the temperature jump by eliminating the need to open the cryostat used to cool the sample. This is achieved by inserting the sample through an airlock in combination with a dedicated dissolution system that is inserted through the same airlock shortly before the melting event. The advantages are threefold: (1) the cryostat can be operated continuously at low temperatures. (2) The melting process is rapid as no pressurization steps of the cryostat are required. (3) Blockages of the dissolution system due to freezing of solvents during melting and transfer are minimized.
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