Evidence map›Paper›PMID 37904769›Full record

ArticleMagnetic resonance (Gottingen, Germany)2021

Extended Bloch-McConnell equations for mechanistic analysis of hyperpolarized

Thomas R Eykyn, Stuart J Elliott, Philip W Kuchel

Open access · goldAbstract read
In one paragraph

Article in Magnetic resonance (Gottingen, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Introduction to "Geoffrey Bodenhausen Festschrift".Magnetic resonance (Gottingen, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Thomas R EykynSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, United Kingdom.
Stuart J ElliottCentre de Résonance Magnétique Nucléaire à Très Hauts Champs - FRE 2034 Université de Lyon / CNRS / Université Claude Bernard Lyon 1 / ENS de Lyon, 5 Rue de la Doua, 69100 Villeurbanne, France.
Philip W KuchelSchool of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
St Thomas' Hospital · GBThe University of Sydney · AUUniversité Claude Bernard Lyon 1 · FR

Funding

Wellcome Trust
6 · The paper itself

Abstract

We describe an approach to formulating the kinetic master equations of the time evolution of NMR signals in reacting (bio)chemical systems. Special focus is given to studies that employ signal enhancement (hyperpolarization) methods such as dissolution dynamic nuclear polarization (dDNP) and involving nuclear spin-bearing solutes that undergo reactions mediated by enzymes and membrane transport proteins. We extend the work given in a recent presentation on this topic (Kuchel and Shishmarev, 2020) to now include enzymes with two or more substrates and various enzyme reaction mechanisms as classified by Cleland, with particular reference to non-first-order processes. Using this approach, we can address some pressing questions in the field from a theoretical standpoint. For example, why does binding of a hyperpolarized substrate to an enzyme

Identifiers

PMID37904769
PMCPMC10539799
OpenAlexW3131683928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.