Evidence map›Paper›PMID 37904745›Full record

ArticleArXiv2024

Minimal Mechanisms of Microtubule Length Regulation in Living Cells.

Anna C Nelson, Melissa M Rolls, Maria-Veronica Ciocanel, Scott A McKinley

Open access · greenAbstract readPreprint
In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Anna C NelsonDepartment of Mathematics, Duke University, Durham, 27710, NC, USA.
Melissa M RollsDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, State College, 16801, PA, USA.
Maria-Veronica CiocanelDepartment of Mathematics, Duke University, Durham, 27710, NC, USA.
Scott A McKinleyDepartment of Mathematics, Tulane University, New Orleans, 70118, LA, USA.
Duke University · USPennsylvania State University · USTulane University · US

Funding

Pairing Modeling and Experiment to Understand Microtubule Behavior in Healthy and Injured NeuronsR01NS121245 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Maria-Veronica Ciocanel, Scott A McKinley · 2022 to 2026
$1.5M
NINDS NIH HHS R01 NS121245
6 · The paper itself

Abstract

The microtubule cytoskeleton is responsible for sustained, long-range intracellular transport of mRNAs, proteins, and organelles in neurons. Neuronal microtubules must be stable enough to ensure reliable transport, but they also undergo dynamic instability, as their plus and minus ends continuously switch between growth and shrinking. This process allows for continuous rebuilding of the cytoskeleton and for flexibility in injury settings. Motivated by

Indexed as

microtubule turnoverordinary differential equationsparameterizationstochastic modeling

Identifiers

PMID37904745
PMCPMC10614985
OpenAlexW4388033155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.