Evidence map›Paper›PMID 37904728›Full record

ArticleFrontiers in genetics2023

Rational design of the genetic code expansion toolkit for

Han-Kai Jiang, Jui-Hung Weng, Yi-Hui Wang, Jo-Chu Tsou, Pei-Jung Chen, An-Li Andrea Ko, Dieter Söll, Ming-Daw Tsai, Yane-Shih Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Han-Kai Jiang *Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Jui-Hung Weng *Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Yi-Hui Wang *Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Jo-Chu TsouInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Pei-Jung ChenInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
An-Li Andrea KoInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Dieter SöllDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, United States.
Ming-Daw TsaiInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Yane-Shih WangInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
National Taiwan University · TWYale University · USInstitute of Biological Chemistry, Academia Sinica · TWNational Tsing Hua University · TW

Funding

Studies of Transfer RNAR35GM122560 · NIGMS · YALE UNIVERSITY · PI SOLL, DIETER · 2017 to 2022
$5.6M
NIGMS NIH HHS R35 GM122560
6 · The paper itself

Abstract

Once thought to be non-naturally occurring, D-amino acids (DAAs) have in recent years been revealed to play a wide range of physiological roles across the tree of life, including in human systems. Synthetic biologists have since exploited DAAs' unique biophysical properties to generate peptides and proteins with novel or enhanced functions. However, while peptides and small proteins containing DAAs can be efficiently prepared

Indexed as

amber suppressionD-phenylalanine analogsgenetic code expansionnoncanonical amino acidspyrrolysyl-tRNA synthetasesynthetic biology

Identifiers

PMID37904728
PMCPMC10613524
OpenAlexW4387602652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.