ReviewImmunity, inflammation and disease2023
Potential biomarker for diagnosis and therapy of sepsis: Lactylation.
Review in Immunity, inflammation and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 36 citations in OpenAlex.
- Exercise-induced protein lactylation: From molecular mechanisms to precision health applications.iScience · 2026Review
- Article
- Lactylation in cancer: a new frontier in metabolic-epigenetic regulation and clinical practice.Cell communication and signaling : CCS · 2026Review
- Development and external validation of the HCH and HPMS prognostic indices for sepsis: a retrospective model development study using a Multi-Objective Non-Newtonian Fluid optimization algorithm.BMC medical informatics and decision making · 2026Article
- mRedox biology · 2026Review
- Prognostic determinants of mortality and clinical outcomes in sepsis: a retrospective cohort study.BMC infectious diseases · 2026Article
- Lactate metabolism-driven lactylation: paradoxical modulation of intestinal inflammation and malignancy.Journal of translational medicine · 2026Review
- Prognostic value of the fibrosis-4 index for predicting in-hospital mortality in sepsis patients: evidence from MIMIC-IV and eICU databases.Scientific reports · 2026Article
- Integration of single-cell and bulk transcriptomics with machine learning identifies LDHA as a lactate-related diagnostic and prognostic biomarker in sepsis.BMC infectious diseases · 2026Article
- Association between shock‑lactate index and 28-day mortality in patients with sepsis-associated AKI: a MIMIC-IV database analysis.BMC infectious diseases · 2026Observational
- Jaceosidin Attenuates Sepsis-Induced Myocardial Dysfunction by Promoting SIRT2-Mediated Inhibition of Histone H3K18 Lactylation.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Mitochondrial dysfunction in sepsis-induced immunoparalysis: from immune-cell metabolic reprogramming to clinical biomarkers.Frontiers in immunology · 2026Review
- Combined prognostic value of the neutrophil-to-lymphocyte ratio and serum lactate for 28-day mortality in patients with sepsis-induced pulmonary dysfunction.American journal of translational research · 2026Article
- Changes in plasma inflammatory injury factors and their clinical significance in pediatric bacterial pneumonia and sepsis.Open life sciences · 2026Article
- A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning.Frontiers in immunology · 2026Article
- Metabolic and post-translational modifications in sepsis-associated immune dysfunction: a conceptual framework.Frontiers in immunology · 2026Review
- Machine learning-based multicenter prediction of postoperative sepsis in emergency colon cancer: role of surgical approach and inflammatory markers.Frontiers in oncology · 2026Article
- Lactylation: a novel epigenetic bridge connecting metabolic reprogramming and immune dysregulation in sepsis-associated ARDS.Frontiers in immunology · 2026Review
- Branched-chain amino acids and sepsis: from pathological mechanisms to clinical interventions.Nutrition & metabolism · 2025Review
- Sepsis-Related Cardiomyopathy: Advances in Diagnosis and Treatment.Reviews in cardiovascular medicine · 2025Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAs a disease that has plagued human health for decades, sepsis has so far had no specific diagnostic or therapeutic indicators. The discovery of lactylation modifications not only uncovered the deep-rooted causes of changing between lactate level and pathophysiology and immunology of sepsis, but also reaffirmed the inevitable link between metabolic reprogramming and epigenetic reprogramming in sepsis. Lactylation modification became a potential marker for diagnosis and guiding the treatment of sepsis.
aimIn this paper, we will summarize the discovery and regulation of lactylation modifications, discuss the study of lactylation modifications in sepsis, and evaluate their possibility and potential as diagnostic and therapeutic indicators of sepsis.
conclusionLactylation modification is directly regulated by glycolysis and lactate, and inhibition of glycolytic pathway-related enzymes can regulate the level of lactylation modification, and more importantly, lactylation modification can act on these enzymes to regulate their functions and feedback regulate the level of glycolysis, this finding provides more ideas for clinical treatment of sepsis. We use "epigenetic modification", "glycolysis", "lactate", "lactylaiton" and "sepsis" as keywords and search the relevant literature through Pubmed and Web of science up to 2023.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.