Evidence map›Paper›PMID 37904566›Full record

ArticleCurrent aging science2024

Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major Neurocognitive Disorders.

Inês Marques-Aleixo, Arnaldina Sampaio, Lucimére Bohn, Flavia Machado, Duarte Barros, Oscár Ribeiro, Joana Carvalho, José Magalhães

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Article in Current aging science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Inês Marques-AleixoInterdisciplinary Research Centre for Education and Development, Lusófona University, Lisbon, Portugal.
Arnaldina SampaioResearch Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal.
Lucimére BohnInterdisciplinary Research Centre for Education and Development, Lusófona University, Lisbon, Portugal.
Flavia MachadoResearch Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal.
Duarte BarrosResearch Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal.
Oscár RibeiroCINTESIS - Center for Health Technology and Services Research, Department of Education and Psychology, University of Aveiro, Aveiro, Portugal.
Joana CarvalhoResearch Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal.
José MagalhãesResearch Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal.

Funding

Laboratory for Integrative and Translational Research in Population Health SFRH/BD/136635/2018, 2020.05911.BD, POCI-01-0145-FEDER-031808Portuguese Foundation for Science and Technology (FCT) [FCT/UIDB/00617/2020]
6 · The paper itself

Abstract

backgroundNeuropsychiatric symptoms (NPS) are highly prevalent among individuals with major neurocognitive disorders (MNCD).

objectiveHere, we characterized blood biomarkers (metabolic, inflammatory, neurotrophic profiles and total antioxidant), body composition, physical fitness and quality of life (QoL) in individuals with MNCD according to NPS.

methodsThe sample comprised 34 older adults (71.4% women; 74.06±6.03 yrs, with MNCD diagnosis) categorized according to 50th percentile [Low (≤12) or High (≥13)] for NPS (Neuropsychiatric Inventory Questionnaire). Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (ADAS-Cog), physical fitness (Senior Fitness Test), QoL (QoL-Alzheimer's Disease scale) were evaluated, and blood samples were collected for biochemical analysis.

resultsLow compared to high NPS group showed higher levels of IL-6, IGF-1and neurotrophic zscore (composite of IGF-1, VEGF-1, BDNF). Additionally, low compared to high NPS group have higher QoL, aerobic fitness and upper body and lower body strength.

conclusionThe severity of NPS seems to be related to modified neurotrophic and inflammatory outcomes, lower physical fitness, and poor QoL. Strategies to counteract NPS development may preserve the physical and mental health of individuals with MNCD.</p>.

Indexed as

BiomarkersBrain-Derived Neurotrophic FactorCognitionInsulin-Like Growth Factor IPhysical FitnessQuality of LifeAgedAged, 80 and overAge FactorsBody CompositionCross-Sectional StudiesFemaleHumansInflammation MediatorsInterleukin-6MaleBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorIGF1 protein, humanIL6 protein, humanInflammation MediatorsInsulin-Like Growth Factor IInterleukin-6Vascular Endothelial Growth Factor AVEGFA protein, humanalzheimer diseaseBlood biomarkersdementiaMNCD.neuropsychiatric inventory questionnaireneuropsychiatric symptoms (NPS)seniors

Identifiers

PMID37904566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.