ReviewGenome medicine2023
Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions.
Review in Genome medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Genetic and environmental risk factors for dementia in African adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa.International journal of molecular sciences · 2026Review
- DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations.American journal of human genetics · 2026Article
- Polygenic risk scores in clinical applications - opportunities and challenges.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026Article
- Adolescent pain reports share genetic overlap with adult chronic pain conditions: A polygenic score analysis using the ABCD study.The journal of pain · 2026Article
- Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries.Nature communications · 2026Article
- S4-multi: Enhancing polygenic score prediction in ancestrally diverse populations.HGG advances · 2026Article
- Analysis of left ventricular mass for African American individuals using multi-ancestry polygenic risk scores: the Jackson Heart Study.Open heart · 2025Article
- Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries.Research square · 2025Article
- Methods for multiancestry genome-wide association study meta-analysis.Annals of human genetics · 2025Review
- DiscoDivas: Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations.medRxiv : the preprint server for health sciences · 2025Article
- Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations.Circulation. Genomic and precision medicine · 2025Article
- Driving Global Health equity and precision medicine through African genomic data.Human molecular genetics · 2025Article
- Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Dental genomics in Africa: colonial legacies and research gaps.Frontiers in oral health · 2025Article
- Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.JAMA ophthalmology · 2025Article
- Rethinking Parkinson's disease genetics in the precision medicine era: why genomic diversity matters?Frontiers in genetics · 2025Article
- The PRIMED Consortium: Reducing disparities in polygenic risk assessment.American journal of human genetics · 2024Article
- Polygenic prediction for underrepresented populations through transfer learning by utilizing genetic similarity shared with European populations.Briefings in bioinformatics · 2024Article
- Inclusiveness of the All of Us Research Program improves polygenic risk scores and fosters genomic medicine for all.Communications medicine · 2024Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 7 countries.
Funding
Abstract
Early identification of genetic risk factors for complex diseases can enable timely interventions and prevent serious outcomes, including mortality. While the genetics underlying many Mendelian diseases have been elucidated, it is harder to predict risk for complex diseases arising from the combined effects of many genetic variants with smaller individual effects on disease aetiology. Polygenic risk scores (PRS), which combine multiple contributing variants to predict disease risk, have the potential to influence the implementation for precision medicine. However, the majority of existing PRS were developed from European data with limited transferability to African populations. Notably, African populations have diverse genetic backgrounds, and a genomic architecture with smaller haplotype blocks compared to European genomes. Subsequently, growing evidence shows that using large-scale African ancestry cohorts as discovery for PRS development may generate more generalizable findings. Here, we (1) discuss the factors contributing to the poor transferability of PRS in African populations, (2) showcase the novel Africa genomic datasets for PRS development, (3) explore the potential clinical utility of PRS in African populations, and (4) provide insight into the future of PRS in Africa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.