Dose-effect relationship of linear accelerator based stereotactic radiotherapy for brain metastases.

Ning Wu, Zhiqiang Wang, Xin Guo, Hongfu Zhao

Open access · goldAbstract read

In one paragraph

Article in Radiation oncology (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.5field-weighted citation impact, top 28% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Ning WuDepartment of Radiation Oncology, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, 130033, Changchun City, Jilin, PR China.

Zhiqiang WangDepartment of Radiation Oncology, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, 130033, Changchun City, Jilin, PR China.

Xin GuoDepartment of Radiation Oncology, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, 130033, Changchun City, Jilin, PR China.

Hongfu ZhaoDepartment of Radiation Oncology, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, 130033, Changchun City, Jilin, PR China. zhaohf@jlu.edu.cn.

Jilin University · CNUnion Hospital · CNUnion Hospital · CN

Funding

National Natural Science Foundation of China 81201737Project of Science and Technology Development Plan of Jilin Province 20200201524JCScientific Research Project of Education Department of Jilin Province JJKH20211196KJ

6 · The paper itself

Abstract

objectiveThe purpose of this study is to reveal the dose-effect relationship of linear accelerator (LINAC)-based stereotactic radiotherapy (SRT) in patients with brain metastases (BM). MATERIALS AND

methodsThe PubMed, Cochrane, and Web of Science databases were used to identify studies that reported local tumour control after LINAC-based SRT in patients with BMs. Studies of other approaches that could affect local tumour control, such as whole brain radiotherapy, targeted therapy, and immunotherapy, were excluded from the dose-effect relationship analysis. Data extracted included patient and treatment characteristics and tumour local control. Probit model in XLSTAT 2016 was used for regression analysis, and P < 0.05 was set as the statistically significant level.

resultsAfter literature screening, 19 eligible studies involving 1523 patients were included in the probit model regression analysis. There was no significant dose-effect relationship between nominal BED

conclusionFor patients with BM treated with LINAC-based SRT, more attention should be given to the central and average doses of PTV. A clear definition of the dose prescription should be established to ensure the effectiveness and comparability of treatment.

Indexed as

Brain NeoplasmsRadiosurgeryHumansParticle AcceleratorsRetrospective StudiesBrain metastasesDose-effect relationshipLinear acceleratorStereotactic radiotherapy

Identifiers

PMID37904212

DOI10.1186/s13014-023-02360-y

PMCPMC10617179

OpenAlexW4388035171

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.