Evidence map›Paper›PMID 37904200›Full record

ArticleAIDS research and therapy2023

Mixed methods implementation research to understand success of intensive combination approach to roll back the epidemic in Nigerian adolescents) (iCARE Nigeria) HIV testing uptake and linkage to care among young men focusing on young men who have sex with men in Ibadan.

Lisa R Hirschhorn, Adedotun Adetunji, Aima A Ahonkhai, Bibilola Oladeji, Olutosin A Awolude, Lisa M Kuhns, Jude Onumabor, Kehinde M Kuti, Olayinka Omigbodun, Amy K Johnson and 3 more

Abstract read
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Article in AIDS research and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

13 authors.

Lisa R HirschhornDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, 625 N Michigan Ave, 14-013, Chicago, IL, 60611, USA. Lisa.Hirschhorn@northwestern.edu.
Adedotun AdetunjiDepartment of Family Medicine, University College Hospital, Ibadan, Nigeria.
Aima A AhonkhaiDepartment of Medicine, Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.
Bibilola OladejiDepartment of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Olutosin A AwoludeDepartment of Obstetrics and Gynecology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Lisa M KuhnsDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jude OnumaborInitiative for the Advancement of Improved Health and Development, I-AIHD, Ibadan, Nigeria.
Kehinde M KutiInfectious Disease Institute, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Olayinka OmigbodunDepartment of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Amy K JohnsonDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ogochukwu OkonkworDivision of Infectious Diseases and Center for Global Health, Northwestern University, Chicago, IL, USA.
Babafemi TaiwoDivision of Infectious Diseases and Center for Global Health, Northwestern University, Chicago, IL, USA.
Robert GarofaloDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Funding

Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian AdolescentsUH3HD096920 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TAIWO, BABAFEMI O · 2020 to 2022
$4.6M
Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian AdolescentsUG3HD096920 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GAROFALO, ROBERT, TAIWO, BABAFEMI O · 2018 to 2020
$2.0M
NICHD NIH HHS UG3 HD096920NICHD NIH HHS UH3 HD096920
6 · The paper itself

Abstract

backgroundHIV seroprevalence in Nigeria is increasing among men who have sex with men (MSM) from 14% to 2007 to 23% in 2014, threatening progress towards ending the epidemic in the country. Expanding access to HIV testing and linkage to care for key populations, like young MSM (YMSM), is critical to end the HIV epidemic in Nigeria. The Intensive Combination Approach to Roll Back the Epidemic in Nigerian Adolescents (iCARE Nigeria) pilot intervention successfully implemented a combination of evidence-based interventions utilizing peer navigators and popular social media apps and platforms to reach young men at risk for HIV exposure, including YMSM. We conducted sequential mixed methods explanatory implementation research to expand on the previously reported effectiveness and implementation outcomes and to explore the determinants and strategies which contributed to primary study results.

methodsWe conducted key informant interviews and focus group discussions with 2 peer navigators and 3 study staff at the end of the pilot. We used directed content analysis to understand the quantitative results from the pilot. Using the Implementation Research Logic Model, we were able to identify and map strategies through mechanisms of action from barriers addressed to the reported implementation outcomes including feasibility, acceptability fidelity and adoption.

resultsWe found that iCARE Nigeria's pilot intervention implementers reported high feasibility, acceptability fidelity and adoption were associated with implementation of strategies which addressed many challenging contextual factors, including social stigma, online social networking, legal barriers surrounding MSM behavior, and the COVID-19 pandemic. These strategies included integration of stakeholders' interests, selection of experienced peer navigators including from the targeted population, training and supportive supervision using an implementation guide, ensuring safety (COVID and legal) and identification of clinics serving the targeted population.

conclusionMixed methods using implementation research frameworks provided insights into the strategies and barriers and facilitators they addressed which may explain the success of the pilot. These results can inform strategies needed to scale-up the intervention to youth including YMSM in other areas in Nigeria and the region. TRIAL REGISTRATION ISRCTN: ISRCTN94590823, https://doi.org/10.1186/ISRCTN94590823.

Indexed as

HIV InfectionsSexual and Gender MinoritiesAdolescentHIV TestingHomosexuality, MaleHumansMaleNigeriaPandemicsSeroepidemiologic StudiesHIVHIV testingImplementation scienceMen who have sex with menNigeria

Identifiers

PMID37904200
PMCPMC10617228

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.