ArticleJournal of orthopaedic surgery and research2023
Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study.
Article in Journal of orthopaedic surgery and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A systematic review of the association between insulin resistance surrogate indices and bone mineral density.Frontiers in endocrinology · 2024Pooled it
- Comparison of Bone Microarchitecture and Clinical Biomarkers between Diabetic and Non-Diabetic Postmenopausal Osteoporotic Women.Journal of bone metabolism · 2026Article
- Joint association of weekend catch-up sleep and triglyceride-glucose index on bone loss and all-cause mortality in employed U.S. adults aged 18-60 with diabetes.Lipids in health and disease · 2026Article
- The association between blood lipid levels and the risk of atrophic gastritis: a cross-sectional study of the Wuwei cohort.Frontiers in public health · 2026Article
- Real-world safety profile of givinostat: an early post-marketing pharmacovigilance study based on the FAERS database.Frontiers in pharmacology · 2026Article
- Associations of six adiposity indices with incident back pain and the mediating role of the triglyceride-glucose index: prospective findings from the UK biobank.Frontiers in nutrition · 2026Article
- Article
- Unveiling the Causal Relationship Between Osteoporosis and Circulating Metabolites from a Genetic Perspective.Journal of musculoskeletal & neuronal interactions · 2025Article
- Association of metabolic score for visceral fat (METS-VF) with lumbar spine bone mineral density in US adults.Scientific reports · 2025Article
- Association of triglycerides with bone mineral density in children and adolescents: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Association between Non high density lipoprotein to high density lipoprotein cholesterol ratio and bone mineral density.Scientific reports · 2025Article
- Development and validation of a novel glucolipid metabolism-related nomogram to enhance the predictive performance for osteoporosis complications in prediabetic and diabetic patients.Lipids in health and disease · 2025Article
- Immune Cells as Mediators of Lipidome Influence on Osteoporosis: Evidence from a Mediation Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Association between triglyceride‑glucose index and lumbar bone mineral density among Chinese individuals with osteoporotic fractures: a cross sectional study.Scientific reports · 2025Article
- Association between the Triglyceride-glucose index and fragility fractures among US adults: insights from NHANES.Diabetology & metabolic syndrome · 2025Article
- Association of triglyceride-glucose index with bone mineral density and fracture: a systematic review.Diabetology & metabolic syndrome · 2025Review
- The association of lipids and novel non-statin lipid-lowering drug target with osteoporosis: evidence from genetic correlations and Mendelian randomization.BMC musculoskeletal disorders · 2025Article
- Development and evaluation of interpretable machine learning regressors for predicting femoral neck bone mineral density in elderly men using NHANES data.Biomolecules & biomedicine · 2025Article
- Correlations Between TyG-Related Indices and Bone Health: A Cross-Sectional Study of Osteoporosis in a Rural Chinese Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Evaluating the triglyceride glucose index as a predictive biomarker for osteoporosis in patients with type 2 diabetes.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveDisorders in glucose and lipid metabolism have been shown to exert an influence on bone metabolism. The TyG index, which combines measures of glucose and triglycerides, provides insights into the overall metabolic status. However, the investigation of concurrent disturbances in glucose and lipid metabolism and their specific implications for bone metabolism remains limited in the existing research literature. This study aimed to explore the correlation between the TyG index and bone mineral density (BMD) in US adults.
methodsIn the National Health and Nutrition Examination Survey (NHANES), subjects were classified based on the TyG index into four groups (< 7.97, 7.97-8.39, 8.39-8.85, > 8.86). Linear regression analysis was conducted to determine the β value and 95% confidence interval (CI). Four multivariable models were constructed. Restricted cubic spline analyses and piecewise linear regression were employed to identify the association between the BMD and TyG index. An analysis of subgroups was also conducted in this study.
resultsSignificant variations in related characteristics were found among the US adult population, who were distributed into four groups based on the quartiles of the TyG index. A negative correlation between the TyG index and lumbar spine BMD was observed. In the multi-adjusted models, compared to Q1 of the TyG index, the β for Q4 of the TyG index for lumbar spine BMD was [β = - 0.008, 95% CI (- 0.017, 0)] in US adults. The association between the TyG index and lumbar spine BMD was found to be nonlinear (all nonlinear p < 0.001), with a threshold value based on restricted cubic spline analyses. Above the threshold point, the β for lumbar spine BMD was - 0.042 (95% CI, - 0.059, - 0.024). Below the threshold points, no significant difference was observed (p > 0.05). No significant interactions were observed among subgroups based on age, gender, presence of diabetes, BMI, and use of antidiabetic and antihyperlipidemic agents. Similar patterns of association were observed in total and subtotal bone density.
conclusionsThis study identified a nonlinear association between the TyG index and BMD in the US population. Furthermore, an increased level of the TyG index may indicate a higher risk of osteoporosis among US adults. These findings highlight the importance of considering glucose and lipid metabolism disturbances in understanding bone health and the potential for developing preventive strategies for osteoporosis.
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