ArticleNature human behaviour2024
Self-regulating arousal via pupil-based biofeedback.
Article in Nature human behaviour, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed.
- Transcutaneous auricular vagus nerve stimulation during short-term motor practice drives cortical plasticity without behavioural improvement.The Journal of physiology · 2026Trial
- Neural and autonomic predictors of future listening errors.bioRxiv : the preprint server for biology · 2026Article
- Phoneme Monitoring in Developmental Dyslexia: Pupillometric Evidence for Cognitive Rather than Acoustic Origins of Phonological Deficits.Brain sciences · 2026Article
- Article
- Polarizer-assisted pupillometry through closed eyelids, overcoming pupil position dependence.Journal of biomedical optics · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Neural Oscillations Track Subjective and Pupillary Arousal During Naturalistic Movie Viewing.The European journal of neuroscience · 2026Article
- Article
- Pupil-based arousal self-regulation: impact on physiological and affective responses to emotional stimuli.Translational psychiatry · 2026Article
- Electroencephalography, pupillometry, and behavioral evidence for locus coeruleus-noradrenaline system related tonic hyperactivity in older adults.Neurobiology of aging · 2026Article
- Dissociable Pupil and Oculomotor Markers of Attention Allocation and Distractor Suppression during Listening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Rhythmic Embodied Perception Framework of breath, brain, and perception.Neuroscience of consciousness · 2026Review
- Sighs Shape Respiratory Variability and Pupil Dynamics and Adapt to Sustained Attention Demands.Psychophysiology · 2026Article
- Modulating cortical excitability and cortical arousal by pupil self-regulation.Nature communications · 2025Article
- Locus coeruleus-related insula activation supports implicit learning.bioRxiv : the preprint server for biology · 2025Article
- Subcortical nuclei of the human ascending arousal system encode anticipated reward but do not predict subsequent memory.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Oscillations of the Wandering Mind: Neural Evidence for Distinct Exploration/Exploitation Strategies in Younger and Older Adults.Human brain mapping · 2025Article
- Paced Breathing Associated With Pupil Diameter Oscillations at the Same Rate and Reduced Lapses in Attention.Psychophysiology · 2025Article
- Arousal and sustained attention fluctuate differently with respiration in younger and older adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- What can ANS signals tell us about motor learning? An implication for better assessment of cognitive contribution to motor learning.Frontiers in behavioral neuroscience · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The brain's arousal state is controlled by several neuromodulatory nuclei known to substantially influence cognition and mental well-being. Here we investigate whether human participants can gain volitional control of their arousal state using a pupil-based biofeedback approach. Our approach inverts a mechanism suggested by previous literature that links activity of the locus coeruleus, one of the key regulators of central arousal and pupil dynamics. We show that pupil-based biofeedback enables participants to acquire volitional control of pupil size. Applying pupil self-regulation systematically modulates activity of the locus coeruleus and other brainstem structures involved in arousal control. Furthermore, it modulates cardiovascular measures such as heart rate, and behavioural and psychophysiological responses during an oddball task. We provide evidence that pupil-based biofeedback makes the brain's arousal system accessible to volitional control, a finding that has tremendous potential for translation to behavioural and clinical applications across various domains, including stress-related and anxiety disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.