Evidence map›Paper›PMID 37903990›Full record

ArticleCell death and differentiation2023

YTHDC1 as a tumor progression suppressor through modulating FSP1-dependent ferroptosis suppression in lung cancer.

Shuai Yuan, Shu Xi, Hong Weng, Meng-Meng Guo, Jin-Hui Zhang, Zhi-Ping Yu, Haozhe Zhang, Zhaojun Yu, Zengzhen Xing, Meng-Yang Liu and 9 more

Open access · greenAbstract read
In one paragraph

Article in Cell death and differentiation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
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  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. RNA modifications and cancer ferroptosis.Cancer cell international · 2026
    Review
  10. Article
  11. Article
  12. TRMT6/TRMT61A-mediated tRNA mCellular & molecular biology letters · 2026
    Article
  13. Article
  14. Review
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  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Shuai Yuan *Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.ORCID 0000-0002-8503-612X
Shu Xi *Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Hong Weng *Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Meng-Meng GuoCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jin-Hui ZhangCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhi-Ping YuCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.ORCID 0000-0002-4626-9676
Haozhe ZhangDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Zhaojun YuDepartment of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Zengzhen XingDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Meng-Yang LiuCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Dao-Jing MingCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Rajiv Kumar SahDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Yi ZhouDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Gang LiCancer Center, Faculty of Health Sciences, MoE Frontier Science Center for Precision Oncology, University of Macau, Taipa, Macau, SAR, China.ORCID 0000-0003-3203-8567
Tao ZengDepartment of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.ORCID 0000-0002-9350-937X
Xin HongDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID 0000-0002-9671-0116
Yafei LiDepartment of Epidemiology, College of Preventive Medicine, Army Medical University, Chongqing, China. liyafei2008@hotmail.com.
Xian-Tao ZengCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. zengxiantao1128@whu.edu.cn.ORCID 0000-0003-1262-725X
Hailiang HuDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China. huhl@sustech.edu.cn.ORCID 0000-0001-9205-1603
Wuhan University · CNSouthern University of Science and Technology · CNNanchang University · CNArmy Medical University · CNUniversity of Macau · MO

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82002447National Natural Science Foundation of China (National Science Foundation of China) 82173131
6 · The paper itself

Abstract

Ferroptosis is a regulated cell death process initiated by iron-dependent phospholipid peroxidation and is mainly suppressed by GPX4-dependent and FSP1-dependent surveillance mechanisms. However, how the ferroptosis surveillance system is regulated during cancer development remains largely unknown. Here, we report that the YTHDC1-mediated m

Indexed as

FerroptosisLung NeoplasmsRegulated Cell DeathApoptosis Regulatory ProteinsEpigenesis, GeneticHumansMitochondrial ProteinsNerve Tissue ProteinsPolyadenylationRNA, MessengerRNA Splicing FactorsApoptosis Regulatory Proteinsferroptosis suppressor protein 1, humanMitochondrial ProteinsNerve Tissue ProteinsRNA, MessengerRNA Splicing FactorsYTHDC1 protein, human

Identifiers

PMID37903990
PMCPMC10733405
OpenAlexW4388023375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.