ArticleNature immunology2023
E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.
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Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
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48 citing papers in PubMed, 81 citations in OpenAlex.
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Authors and funding
26 authors at 7 institutions in 3 countries.
Monika Pruenster *Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Roland Immler *Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.ORCID 0000-0002-4086-7528
Jonas RothWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Tim KuchlerWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.ORCID 0009-0006-4499-1223
Thomas BrombergerInstitute of Experimental Hematology, School of Medicine, Technical University Munich, Munich, Germany.
Matteo NapoliWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.ORCID 0000-0002-8197-9374
Katrin NussbaumerWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Ina RohwedderWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Lou Martha WackerbarthWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Chiara PiantoniWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.ORCID 0000-0002-3621-8402
Konstantin HennisWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.ORCID 0000-0003-0343-0068
Diana FinkDepartment of Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.
Sebastian KallabisDepartment of Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.
Tobias SchrollWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.ORCID 0009-0007-4647-3961
Sergi Masgrau-AlsinaWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Agnes BudkeWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Wang LiuWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Dietmar VestweberMax Planck Institute for Molecular Biomedicine, Münster, Münster, Germany.ORCID 0000-0002-3517-732X
Christian Wahl-SchottWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Johannes RothInstitute of Immunology, University of Münster, Münster, Germany.ORCID 0000-0001-7035-8348
Felix MeissnerDepartment of Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0003-1000-7989
Markus MoserInstitute of Experimental Hematology, School of Medicine, Technical University Munich, Munich, Germany.
Thomas VoglInstitute of Immunology, University of Münster, Münster, Germany.ORCID 0000-0001-9669-7479
Veit HornungGene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0002-4150-194X
Petr BrozDepartment of Immunobiology, University of Lausanne, Epalinges, Switzerland.ORCID 0000-0002-2334-7790
Markus SperandioWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany. markus.sperandio@lmu.de.ORCID 0000-0002-7689-3613
Ludwig-Maximilians-Universität München · DEUniversity of Bonn · DEUniversity of Münster · DETechnical University of Munich · DECentre of Experimental Medicine of the Slovak Academy of Sciences · SKMax Planck Institute for Molecular Biomedicine · DEUniversity of Lausanne · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is unclear. Here, we show that E-selectin-induced rapid S100A8/S100A9 release during inflammation occurs in an NLRP3 inflammasome-dependent fashion. Mechanistically, E-selectin engagement triggers Bruton's tyrosine kinase-dependent tyrosine phosphorylation of NLRP3. Concomitant potassium efflux via the voltage-gated potassium channel K
Indexed as
InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinCalgranulin ACalgranulin BE-SelectinGasderminsHumansInflammationNeutrophilsCalgranulin ACalgranulin BE-SelectinGasderminsInflammasomesNLR Family, Pyrin Domain-Containing 3 Protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.