Evidence map›Paper›PMID 37903857›Full record

ArticleNPJ digital medicine2023

A randomized, clinical trial investigating the use of a digital intervention to reduce delirium-associated agitation.

Michelle Nicholas, Jessica Wittmann, Monica Norena, Marlena Ornowska, Steven Reynolds

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07051096 (Responsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07051096 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Responsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2025 to 2027Enrolled60ConditionsDelirium - Postoperative, Agitation, Anxiety, Cardiac Surgery RecoveryArmsA novel device developed providing nature-driven responsive imagery that responds to the patient's physiological to distract, engage, and de-escalate behaviours of delirium., Routine post-operative management and standard delirium reduction measures.
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. The Neuropsychiatric Disturbances of Delirium: A Review of Syndromes and Their Treatment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Review
  3. Bridging Gaps in Sundown Syndrome Research: a Scoping Review and Roadmap for Future Multimodal Approaches.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Michelle NicholasIntensive Care Unit, Fraser Health Authority C/O Royal Columbian Hospital, New Westminster, BC, V3L 3W7, Canada.ORCID http://orcid.org/0000-0003-1944-3250
Jessica WittmannIntensive Care Unit, Fraser Health Authority C/O Royal Columbian Hospital, New Westminster, BC, V3L 3W7, Canada.ORCID http://orcid.org/0000-0002-6585-4272
Monica NorenaCentre for Health Evaluation and Outcome Sciences, Vancouver, BC, V6Z 1Y6, Canada.
Marlena OrnowskaDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.ORCID http://orcid.org/0000-0002-2635-1189
Steven ReynoldsIntensive Care Unit, Fraser Health Authority C/O Royal Columbian Hospital, New Westminster, BC, V3L 3W7, Canada. sreynolds.md@gmail.com.ORCID http://orcid.org/0000-0002-2624-640X
Royal Columbian Hospital · CACentre for Advancing Health Outcomes · CASimon Fraser University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to determine if a novel digital therapeutic intervention could reduce agitation and unscheduled medication use in an adult delirious acute care population. Delirious participants were randomly allocated (1:1) to receive standard of care plus a single 4-hour exposure to the digital intervention "MindfulGarden", which uses a screen-based delivery to display a nature landscape with dynamic adjustment of screen content in response to movement and sound or standard of care only. Between March 2021 and January 2022, 73 participants were enrolled with 70 completing the trial protocol and included in the final analysis with a mean age of 61 years and 68% being male (35 intervention, 35 control). Mean RASS was significantly lower across the 4-hour study period in the intervention arm 0.3 (0.85) vs 0.9 (0.93), p = 0.01. Exposure to a nature-based dynamic digital intervention showed benefits in agitation reduction.

Identifiers

PMID37903857
PMCPMC10616287
OpenAlexW4388018182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.