Evidence map›Paper›PMID 37903816›Full record

ArticleNature communications2023

An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1.

Yandong Zhou, Michelle R Jennette, Guolin Ma, Sarah A Kazzaz, James H Baraniak, Robert M Nwokonko, Mallary L Groff, Marcela Velasquez-Reynel, Yun Huang, Youjun Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025
    Review
  7. Inter-membrane control of junctional InsPTrends in cell biology · 2025
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Yandong Zhou *Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. zhouyd@psu.edu.ORCID 0000-0003-3503-0296
Michelle R Jennette *Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Guolin MaInstitute of Biosciences and Technology, College of Medicine, Texas A&M University, Houston, TX, 77030, USA.ORCID 0000-0001-5460-3446
Sarah A KazzazDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.ORCID 0000-0003-0362-9499
James H BaraniakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Robert M NwokonkoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Mallary L GroffDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.ORCID 0009-0000-5056-3117
Marcela Velasquez-ReynelDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Yun HuangCenter for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, 77030, USA.ORCID 0000-0001-5950-9168
Youjun WangBeijing Key Laboratory of Gene Resources and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, PR China.ORCID 0000-0003-0961-1716
Donald L GillDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. dongill@psu.edu.ORCID 0000-0003-0587-2548
Pennsylvania State University · USBeijing Normal University · CNPrevention Institute · USStanford University · USTexas A&M University · US

Funding

Understanding Store-Operated Calcium Signal TransductionR35GM131916 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2019 to 2023
$2.9M
Understanding Spatial Interactions Between STIM and OraiF31GM125376 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI NWOKONKO, ROBERT M · 2017 to 2018
$61k
The STIM/Orai interface and novel tools to control vascular smooth muscle phenotypeF31HL152619 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BARANIAK, JAMES HENRY · 2020 to 2021
$50k
NHLBI NIH HHS F31 HL152619NIGMS NIH HHS F31 GM125376NIGMS NIH HHS R35 GM131916
6 · The paper itself

Abstract

Ca

Indexed as

CalciumCalcium SignalingCell MembraneDipeptidesORAI1 ProteinStromal Interaction Molecule 1CalciumDipeptideshistidylphenylalanineORAI1 ProteinStromal Interaction Molecule 1

Identifiers

PMID37903816
PMCPMC10616141
OpenAlexW4388035104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.