Evidence map›Paper›PMID 37903812›Full record

ArticleNPJ Parkinson's disease2023

Epigenome-wide association study of peripheral immune cell populations in Parkinson's disease.

Maren Stolp Andersen, Ingvild Sørum Leikfoss, Ina Skaara Brorson, Chiara Cappelletti, Conceicao Bettencourt, Mathias Toft, Lasse Pihlstrøm

Open access · goldAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Maren Stolp AndersenDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Ingvild Sørum LeikfossDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Ina Skaara BrorsonDepartment of Neurology, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-6691-9413
Chiara CappellettiDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Conceicao BettencourtDepartment of Neurodegenerative Disease and Queen Square Brain Bank for Neurological Disorders, Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0001-9090-7690
Mathias ToftDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Lasse PihlstrømDepartment of Neurology, Oslo University Hospital, Oslo, Norway. lasse.pihlstrom@medisin.uio.no.ORCID http://orcid.org/0000-0002-7635-8645
Oslo University Hospital · NONational Hospital for Neurology and Neurosurgery · GB

Funding

Alzheimer's Research UK (ARUK) ARUK-RF2019B-005Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 2017040
6 · The paper itself

Abstract

Understanding the contribution of immune mechanisms to Parkinson's disease pathogenesis is an important challenge, potentially of major therapeutic implications. To further elucidate the involvement of peripheral immune cells, we studied epigenome-wide DNA methylation in isolated populations of CD14

Identifiers

PMID37903812
PMCPMC10616224
OpenAlexW4388034691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.