Evidence map›Paper›PMID 37903644›Full record

ArticleNeurology2023

Fine Particulate Matter and Parkinson Disease Risk Among Medicare Beneficiaries.

Brittany Krzyzanowski, Susan Searles Nielsen, Jay R Turner, Brad A Racette

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  5. Review
  6. A PLAN to address the Parkinson pandemic.Journal of Parkinson's disease · 2025
    Review
  7. Environmental toxins in neurodegeneration - a narrative review.Neurological research and practice · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Environmental Risk Factors for Parkinson's Disease: A Critical Review and Policy Implications.Movement disorders : official journal of the Movement Disorder Society · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Differentiation and regulation of CD4Cellular and molecular life sciences : CMLS · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brittany KrzyzanowskiFrom the Barrow Neurological Institute (B.K., B.A.R.), Phoenix, AZ; Washington University in St. Louis (S.S.N., J.R.T.) MO. brittany.krzyzanowski@barrowneuro.org.ORCID 0000-0002-4774-6120
Susan Searles NielsenFrom the Barrow Neurological Institute (B.K., B.A.R.), Phoenix, AZ; Washington University in St. Louis (S.S.N., J.R.T.) MO.ORCID 0000-0001-7768-4736
Jay R TurnerFrom the Barrow Neurological Institute (B.K., B.A.R.), Phoenix, AZ; Washington University in St. Louis (S.S.N., J.R.T.) MO.ORCID 0000-0001-7787-6244
Brad A RacetteFrom the Barrow Neurological Institute (B.K., B.A.R.), Phoenix, AZ; Washington University in St. Louis (S.S.N., J.R.T.) MO.ORCID 0000-0002-9582-8235
Barrow Neurological Institute · US

Funding

Motor and Cognitive Health Outcomes in a Mn-Exposed African CommunityR01ES025991 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2015 to 2019
$3.7M
Manganese-Induced Neurotoxic Effects Research in South Africa (MINERS)R01ES026891 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2017 to 2021
$3.3M
NOVEL PET MARKERS OF COGNITIVE IMPAIRMENT IN MANGANESENEUROTOXICITYR01ES029524 · NIEHS · WASHINGTON UNIVERSITY · PI CRISWELL, SUSAN · 2019 to 2023
$3.3M
Encephalitic viral infection and susceptibility to dopaminergic neurotoxinsR01ES030937 · NIEHS · COLORADO STATE UNIVERSITY · PI TJALKENS, RONALD · 2019 to 2021
$1.9M
A Nationwide Study of Environmental Risk Factors for Parkinson DiseaseK01ES028295 · NIEHS · WASHINGTON UNIVERSITY · PI SEARLES NIELSEN, SUSAN · 2018 to 2020
$450k
NIEHS NIH HHS K01 ES028295NIEHS NIH HHS R01 ES025991NIEHS NIH HHS R01 ES026891NIEHS NIH HHS R01 ES029524NIEHS NIH HHS R01 ES030937NIOSH CDC HHS R01 OH011661
6 · The paper itself

Abstract

BACKGROUND AND

objectivesNumerous studies suggest that environmental exposures play a critical role in Parkinson disease (PD) pathogenesis, and large, population-based studies have the potential to advance substantially the identification of novel PD risk factors. We sought to study the nationwide geographic relationship between PD and air pollution, specifically PM

methodsWe conducted a population-based geographic study of Medicare beneficiaries aged 66-90 years geocoded to US counties and zip+4. We used integrated nested Laplace approximation to create age, sex, race, smoking, and health care utilization-adjusted relative risk (RR) at the county level for geographic analyses with PM

resultsAmong 21,639,190 Medicare beneficiaries, 89,390 had incident PD in 2009. There was a nationwide association between average annual PM DISCUSSION: State-of-the-art geographic analytic techniques revealed an association between PM

Indexed as

Air PollutantsAir PollutionParkinson DiseaseAgedEnvironmental ExposureHumansMedicareParticulate MatterUnited StatesAir PollutantsParticulate Matter

Identifiers

PMID37903644
PMCPMC10663024
OpenAlexW4388016920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.