ArticleJournal of neurointerventional surgery2024
Re-rupture in ruptured brain arteriovenous malformations: a retrospective cohort study based on a nationwide multicenter prospective registry.
Article in Journal of neurointerventional surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Long-term outcomes after treatment for symptomatic hemorrhage of brain arteriovenous malformations.Annals of medicine · 2026Article
- External validation of the VALE scoring system for hemorrhage risk in pediatric AVM patients.Neurosurgical review · 2026Article
- Ultrafast rebleeding pediatric brain arteriovenous malformation: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Functional and Hemodynamic Restoration After Microsurgical Resection of Compact High-Flow Temporo-Parieto-Occipital Arteriovenous Malformation.Diagnostics (Basel, Switzerland) · 2025Article
- Awake Craniotomy for the Excision of a Pediatric Cerebral Arteriovenous Malformation for Language Preservation: A Case Description.Journal of personalized medicine · 2025Article
- Intracranial Hemorrhage During Pregnancy: An Interdisciplinary Literature Review and a Rare Case Report of Early-Onset Eclampsia with Intracranial Hemorrhage and HELLP Syndrome.Journal of clinical medicine · 2025Review
- Early analysis of data from the British & Irish Brain Arteriovenous Malformations Registry (BIBAR).Brain & spine · 2025Article
- Outcomes of early targeted embolization for ruptured arteriovenous malformation-associated aneurysms: A single-center study.Brain circulationArticle
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Authors and funding
23 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate the natural history of re-rupture in ruptured brain arteriovenous malformations (AVMs) and to provide comprehensive insights into its associated factors and prevention.
methodsThis study included 1712 eligible ruptured AVMs from a nationwide multicenter prospective collaboration registry between August 2011 and September 2021. The natural rupture risk before intervention and the annual rupture risk after intervention were both assessed. Cox proportional hazard regression models and Kaplan-Meier survival curves were used to explore independent factors associated with AVM re-rupture. The correlation between these factors and AVM re-rupture was verified in multiple independent cohorts, and the prevention effect of intervention timing and intervention strategies on AVM re-rupture was further analyzed.
resultsThe annual re-rupture risk in ruptured AVMs was 7.6%, and the cumulative re-rupture risk in the first 1, 3, 5, and 10 years following the initial rupture were 10%, 25%, 37.5%, and 50%, respectively. Cox proportional hazard regression analysis confirmed adult patients, ventricular system involvement, and any deep venous drainage as independent factors associated with AVM re-rupture. The intervention was found to significantly reduce the risk of AVM re-rupture (annual rupture risk 11.34% vs 1.70%, p<0.001), especially in those who underwent surgical resection (annual rupture risk 0.13%).
conclusionsThe risk of re-rupture in ruptured AVMs is high. Adult patients, ventricular system involvement, and any deep venous drainage are independent risk factors for re-rupture. Applying the results universally to all ruptured AVM cases may be biased. Intervention could effectively reduce the risk of re-rupture.
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