Evidence map›Paper›PMID 37903365›Full record

Trial reportAnnals of internal medicine2023

Clinical Effectiveness of Cognitively Enhanced Tai Ji Quan Training on Global Cognition and Dual-Task Performance During Walking in Older Adults With Mild Cognitive Impairment or Self-Reported Memory Concerns : A Randomized Controlled Trial.

Fuzhong Li, Peter Harmer, Elizabeth Eckstrom, Kathleen Fitzgerald, Kerri Winters-Stone

Registry-linked trialAbstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04070703 (Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults), which is not on this map. Cited by 32 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 9 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04070703 nacompletednot on this map

Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults

TypeinterventionalSponsorOregon Research InstituteRan2019 to 2025Enrolled318ConditionsMild Cognitive ImpairmentArmsThe Go for Exercise & Healthy Aging Project
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 9 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Fuzhong LiOregon Research Institute, Springfield, Oregon (F.L., P.H.).ORCID 0000-0001-6644-4702
Peter HarmerOregon Research Institute, Springfield, Oregon (F.L., P.H.).ORCID 0000-0001-9794-1920
Elizabeth EckstromDivision of General Internal Medicine & Geriatrics, Oregon Health & Science University, Portland, Oregon (E.E.).ORCID 0000-0002-5079-5767
Kathleen FitzgeraldMcKenzie-Willamette Medical Center, Springfield, Oregon (K.F.).
Kerri Winters-StoneKnight Cancer Institute, Oregon Health & Science University, Portland, Oregon (K.W.).ORCID 0000-0003-1706-8020
Oregon Health & Science University · USOregon Research Institute · USWillamette University · US

Funding

Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older AdultsR01AG059546 · NIA · OREGON RESEARCH INSTITUTE · PI LI, FUZHONG · 2019 to 2023
$4.3M
NIA NIH HHS R01 AG059546
6 · The paper itself

Abstract

backgroundMild cognitive impairment (MCI) negatively impacts cognition and dual-task abilities. A physical-cognitive integrated treatment approach could mitigate this risk for dementia.

objectiveTo compare the effectiveness of cognitively enhanced tai ji quan versus standard tai ji quan or stretching exercise in improving global cognition and reducing dual-task walking costs in older adults with MCI or self-reported memory concerns.

design3-group, randomized (1:1:1), superiority trial. (ClinicalTrials.gov: NCT04070703).

settingCommunity residential homes.

participants318 older adults with self-reported memory decline or concern and a Clinical Dementia Rating (CDR) global score of 0.5 or lower at baseline.

interventionCognitively enhanced tai ji quan ( MEASUREMENTS: The co-primary endpoints were change in Montreal Cognitive Assessment (MoCA; range, 0 to 30) and dual-task walking costs (difference between single- and dual-task gait speed, expressed in percentage) from baseline to 24 weeks. Secondary outcomes included CDR-Sum of Boxes (CDR-SB), Trail Making Test B, Digit Span Backward (DSB), and physical performance tests. Outcomes were assessed at 16, 24 (primary endpoint), and 48 weeks (6 months after intervention).

resultsA total of 304 participants (96%) completed the 24-week assessment. Cognitively enhanced tai ji quan outperformed standard tai ji quan and stretching with a greater improvement in MoCA score (mean difference, 1.5 points [98.75% CI, 0.7 to 2.2 points] and 2.8 points [CI, 2.1 to 3.6 points], respectively) and in dual-task walking (mean difference, 9.9% [CI, 2.8% to 16.6%] and 22% [CI, 13% to 31%], respectively). The intervention effects persisted at 48-week follow-up. LIMITATION: There was no nonexercise control group; participants had subjective or mild cognitive impairment.

conclusionAmong community-dwelling older adults with MCI, cognitively enriched tai ji quan therapy was superior to standard tai ji quan and stretching exercise in improving global cognition and reducing dual-task gait interference, with outcomes sustained at 48 weeks. PRIMARY FUNDING SOURCE: National Institute on Aging.

Indexed as

Cognitive DysfunctionTai JiAgedCognitionHumansSelf ReportTask Performance and AnalysisTreatment OutcomeWalking

Identifiers

PMID37903365
PMCPMC13527859
OpenAlexW4388017034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.