Evidence map›Paper›PMID 37903316›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024

Costs of Cancer Prevention: Physical and Psychosocial Sequelae of Risk-Reducing Total Gastrectomy.

Amber F Gallanis, Lauren A Gamble, Sarah G Samaranayake, Rachael Lopez, Amanda Rhodes, Suraj Rajasimhan, Grace-Ann Fasaye, Olvan Juma, Maureen Connolly, Stacy Joyce and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Lessons learned from 150 total gastrectomies for prevention of cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2025
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Amber F GallanisCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-0194-5375
Lauren A GambleCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Sarah G SamaranayakeCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-7056-5635
Rachael LopezClinical Center Nutrition Department, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-5165-5125
Amanda RhodesCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Suraj RajasimhanPharmacy Department, National Institutes of Health Clinical Center, Bethesda, MD.
Grace-Ann FasayeCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Olvan JumaASRC Federal, Bethesda, MD.ORCID 0009-0008-6481-5811
Maureen ConnollyClincal Center Nursing Department, National Institutes of Health, Bethesda, MD.
Stacy JoyceCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Ann BergerPain and Palliative Care Service, Clinical Center, National Institutes of Health, Bethesda, MD.
Theo HellerNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-2643-6289
Andrew M BlakelyCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-5013-3851
Jonathan M HernandezCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Jeremy L DavisCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-6334-6936
National Institutes of Health · USNational Institutes of Health Clinical Center · US

Funding

Interrogating the molecular underpinnings of metastatic colonizationZIABC011759 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HERNANDEZ, JONATHAN · 2017 to 2025
$18.9M
Surgical Oncology Program Training ProgramZIEBC012097 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BLAKELY, ANDREW · 2022 to 2025
$17.3M
Molecular Mechanisms Driving Hereditary Diffuse Gastric Cancer SyndromeZIDBC012159 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DAVIS, JEREMY · 2024 to 2024
$714k
6 · The paper itself

Abstract

purposeRisk-reducing surgery for cancer prevention in solid tumors is a pressing clinical topic because of the increasing availability of germline genetic testing. We examined the short- and long-term outcomes of risk-reducing total gastrectomy (RRTG) and its lesser-known impacts on health-related quality of life (QOL) in individuals with hereditary diffuse gastric cancer syndrome.

methodsIndividuals who underwent RRTG as part of a single-institution natural history study of hereditary gastric cancers were examined. Clinicopathologic details, acute and chronic operative morbidity, and health-related QOL were assessed. Validated questionnaires were used to determine QOL scores and psycho-social-spiritual measures of healing.

resultsOne hundred twenty-six individuals underwent RRTG because of a pathogenic or likely pathogenic germline

conclusionRRTG is associated with life-changing adverse events that should be discussed when counseling patients with

Indexed as

AdenocarcinomaStomach NeoplasmsCadherinsGastrectomyGenetic Predisposition to DiseaseGenetic TestingGerm-Line MutationHumansQuality of LifeCadherins

Identifiers

PMID37903316
PMCPMC10824374
OpenAlexW4388017108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.