Evidence map›Paper›PMID 37902878›Full record

ArticleJournal of neurology2024

Gray matter loss relates to dual task gait in Lewy body disorders and aging.

Arsenije Subotic, Myrlene Gee, Krista Nelles, Fang Ba, Mahsa Dadar, Simon Duchesne, Breni Sharma, Mario Masellis, Sandra E Black, Quincy J Almeida and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Arsenije SuboticDepartment of Medicine, Division of Neurology, University of Alberta, 7-112J CSB, 11350-83 Ave NW, Edmonton, AB, T6G 2G3, Canada.
Myrlene GeeDepartment of Medicine, Division of Neurology, University of Alberta, 7-112J CSB, 11350-83 Ave NW, Edmonton, AB, T6G 2G3, Canada.
Krista NellesDepartment of Medicine, Division of Neurology, University of Alberta, 7-112J CSB, 11350-83 Ave NW, Edmonton, AB, T6G 2G3, Canada.
Fang BaDepartment of Medicine, Division of Neurology, University of Alberta, 7-112J CSB, 11350-83 Ave NW, Edmonton, AB, T6G 2G3, Canada.
Mahsa DadarDepartment of Psychiatry, Douglas Mental Health University Health Centre, McGill University, Montreal, QC, Canada.
Simon DuchesneDepartment of Radiology and Nuclear Medicine, Faculty of Medicine, Laval University, Quebec City, QC, Canada.
Breni SharmaCumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Mario MasellisDepartment of Medicine (Division of Neurology), University of Toronto, Toronto, ON, Canada.
Sandra E BlackDepartment of Medicine (Division of Neurology), University of Toronto, Toronto, ON, Canada.
Quincy J AlmeidaMovement Disorders Research and Rehabilitation Centre, Carespace Health and Wellness, Waterloo, ON, Canada.
Eric E SmithCumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Frederico Pieruccini-FariaGait and Brain Lab, Parkwood Institute Lawson Health Research Institute, London, ON, Canada.
Manuel Montero-OdassoGait and Brain Lab, Parkwood Institute Lawson Health Research Institute, London, ON, Canada.
Richard CamicioliDepartment of Medicine, Division of Neurology, University of Alberta, 7-112J CSB, 11350-83 Ave NW, Edmonton, AB, T6G 2G3, Canada. rcamicio@ualberta.ca.ORCID http://orcid.org/0000-0003-2977-8660
Canadian Consortium on Neurodegeneration in Aging (CCNA)
University of Alberta · CASunnybrook Health Science Centre · CAUniversity of Calgary · CAWestern University · CADouglas Mental Health University Institute · CAUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWithin the spectrum of Lewy body disorders (LBD), both Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by gait and balance disturbances, which become more prominent under dual-task (DT) conditions. The brain substrates underlying DT gait variations, however, remain poorly understood in LBD.

objectiveTo investigate the relationship between gray matter volume loss and DT gait variations in LBD.

methodsSeventy-nine participants including cognitively unimpaired PD, PD with mild cognitive impairment, PD with dementia (PDD), or DLB and 20 cognitively unimpaired controls were examined across a multi-site study. PDD and DLB were grouped together for analyses. Differences in gait speed between single and DT conditions were quantified by dual task cost (DTC). Cortical, subcortical, ventricle, and cerebellum brain volumes were obtained using FreeSurfer. Linear regression models were used to examine the relationship between gray matter volumes and DTC.

resultsSmaller amygdala and total cortical volumes, and larger ventricle volumes were associated with a higher DTC across LBD and cognitively unimpaired controls. No statistically significant interaction between group and brain volumes were found. Adding cognitive and motor covariates or white matter hyperintensity volumes separately to the models did not affect brain volume and DTC associations.

conclusionGray matter volume loss is associated with worse DT gait performance compared to single task gait, across cognitively unimpaired controls through and the LBD spectrum. Impairment in DT gait performance may be driven by age-related cortical neurodegeneration.

Indexed as

Alzheimer DiseaseLewy Body DiseaseParkinson DiseaseAgingGaitGray MatterHumansLewy BodiesDual taskGaitLewy body disorder: agingMRI

Identifiers

PMID37902878
OpenAlexW4388023530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.