Evidence map›Paper›PMID 37902839›Full record

ArticleArchives of gynecology and obstetrics2024

Determination of the androgen receptor status of disseminated tumor cells in primary breast cancer patients.

Natalia Krawczyk, Bernadette Jaeger, Piperek-Jäger Martina, Lopez-Cotarelo Rodriguez-Noriega Cristina, Neubacher Melissa, Banys-Paluchowski Maggie, Meier-Stiegen Franziska, Neubauer Hans, Niederacher Dieter, Ruckhäberle Eugen and 5 more

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In one paragraph

Article in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Natalia Krawczyk *Department of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Bernadette Jaeger *Department of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany. bernadette.jaeger@med.uni-duesseldorf.de.ORCID 0000-0002-7861-7276
Piperek-Jäger MartinaDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Lopez-Cotarelo Rodriguez-Noriega CristinaDepartment of Pathology, University of Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Neubacher MelissaDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Banys-Paluchowski MaggieDepartment of Obstetrics and Gynecology, University Hospital of Schleswig Holstein, Campus Lübeck, 23538, Lübeck, Germany.
Meier-Stiegen FranziskaDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Neubauer HansDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Niederacher DieterDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Ruckhäberle EugenDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Mohrmann SvjetlanaDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Hoffmann JürgenDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Kaleta ThomasDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Esposito IreneDepartment of Pathology, University of Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Fehm TanjaDepartment of Obstetrics and Gynaecology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Heinrich Heine University Düsseldorf · DEUniversity of Mannheim · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAndrogen receptor (AR) can serve as a new therapeutic target since it was shown to play a proliferative role in several breast cancer (BC) subtypes. Moreover, AR positivity has been suggested to reflect the metastatic potential of tumor cells in some BC subtypes. The aim of this study was to determine the AR expression on disseminated tumor cells (DTCs) as a surrogate marker of minimal residual disease (MRD) and potential precursor of metastasis in early BC.

methodsBone marrow (BM) aspirates from 62 DTC-positive early BC patients were included into this study and analyzed by immunofluorescence staining for the presence of AR-positive DTCs. CK-positive, CD45-negative cells containing an intact nucleus (DAPI positive) were identified as DTCs. AR expression of the primary tumor (PT) was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded (FFPE) tumor sections from core biopsies and surgical specimens.

resultsAR status of DTCs could be determined in 21 patients. We detected AR-positive DTCs in nine samples (43%). AR expression of DTCs and corresponding PT showed a concordance rate of 33%. The DTC-AR status did not correlate with clinicopathological factors, nor did we observe a significant correlation between the AR status of the PT and other established prognostic factors for BC.

conclusionAR-positive DTCs can be detected in BM of early BC patients with a marked discordance of the AR status between DTCs and corresponding PTs. The clinical significance of these findings needs further investigation.

Indexed as

Breast NeoplasmsNeoplastic Cells, CirculatingFemaleHumansPrognosisReceptors, AndrogenReceptors, AndrogenMinimal residual diseasePredictive markerTargeted therapy

Identifiers

PMID37902839
PMCPMC10894135
OpenAlexW4388021951

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.