Evidence map›Paper›PMID 37902809›Full record

ArticleeLife2023

The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis.

Nydia Tejeda-Munoz, Yagmur Azbazdar, Julia Monka, Grace Binder, Alex Dayrit, Raul Ayala, Neil O'Brien, Edward M De Robertis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nydia Tejeda-Munoz *Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Yagmur Azbazdar *Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Julia MonkaDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Grace BinderDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Alex DayritDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Raul AyalaDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Neil O'BrienDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Edward M De RobertisDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0002-7843-1869
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
NCI NIH HHS P30 CA016042NIH HHS P20CA016042
6 · The paper itself

Abstract

Activation of the Wnt pathway lies at the core of many human cancers. Wnt and macropinocytosis are often active in the same processes, and understanding how Wnt signaling and membrane trafficking cooperate should improve our understanding of embryonic development and cancer. Here, we show that a macropinocytosis activator, the tumor promoter phorbol 12-myristate 13-acetate (PMA), enhances Wnt signaling. Experiments using the

Indexed as

CarcinogensNeoplasmsAnimalsEstersFemaleGlycogen Synthase Kinase 3HumansMicePhorbol EstersPregnancyWnt Signaling PathwayCarcinogensEstersGlycogen Synthase Kinase 3Phorbol Esterscancer biologycolorectal cancerdevelopmental biologylysosomesmacropinocytosisWnt signalingxenopusβ-catenin

Identifiers

PMID37902809
PMCPMC10615368
OpenAlexW4385446121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.