ArticleJournal of cognitive neuroscience2024
Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.
Article in Journal of cognitive neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia.bioRxiv : the preprint server for biology · 2026Article
- Article
- Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations.Cell reports · 2025Article
- Neural models for detection and classification of brain states and transitions.Communications biology · 2025Article
- Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025Review
- Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Anesthesia and the neurobiology of consciousness.Neuron · 2024Review
- Widespread, perception-related information in the human brain scales with levels of consciousness.Imaging neuroscience (Cambridge, Mass.) · 2024Article
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7 authors at 3 institutions in 1 country.
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Abstract
A critical component of anesthesia is the loss of sensory perception. Propofol is the most widely used drug for general anesthesia, but the neural mechanisms of how and when it disrupts sensory processing are not fully understood. We analyzed local field potential and spiking recorded from Utah arrays in auditory cortex, associative cortex, and cognitive cortex of nonhuman primates before and during propofol-mediated unconsciousness. Sensory stimuli elicited robust and decodable stimulus responses and triggered periods of stimulus-related synchronization between brain areas in the local field potential of Awake animals. By contrast, propofol-mediated unconsciousness eliminated stimulus-related synchrony and drastically weakened stimulus responses and information in all brain areas except for auditory cortex, where responses and information persisted. However, we found stimuli occurring during spiking Up states triggered weaker spiking responses than in Awake animals in auditory cortex, and little or no spiking responses in higher order areas. These results suggest that propofol's effect on sensory processing is not just because of asynchronous Down states. Rather, both Down states and Up states reflect disrupted dynamics.
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