Evidence map›Paper›PMID 37902400›Full record

ArticleJournal of virology2023

The expression and function of HSV ICP47 and its promoter in mice.

Thilaga Velusamy, Navneet Singh, Sarah Croft, Stewart Smith, David C Tscharke

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Thilaga VelusamyJohn Curtin School of Medical Research, The Australian National University , Canberra, ACT, Australia.
Navneet Singh *John Curtin School of Medical Research, The Australian National University , Canberra, ACT, Australia.ORCID 0000-0001-9195-4966
Sarah Croft *John Curtin School of Medical Research, The Australian National University , Canberra, ACT, Australia.
Stewart SmithJohn Curtin School of Medical Research, The Australian National University , Canberra, ACT, Australia.
David C TscharkeJohn Curtin School of Medical Research, The Australian National University , Canberra, ACT, Australia.ORCID 0000-0001-6825-9172
Australian National University · AU

Funding

Department of Education and Training | Australian Research Council (ARC) DP190101325DHAC | National Health and Medical Research Council (NHMRC) GNT1126599, GNT1084342, GNT2003395, GNT2008990
6 · The paper itself

Abstract

importanceImmune evasion and latency are key mechanisms that underlie the success of herpesviruses. In each case, interactions between viral and host proteins are required and due to co-evolution, not all mechanisms are preserved across host species, even if infection is possible. This is highlighted by the herpes simplex virus (HSV) protein immediate early-infected cell protein (ICP)47, which inhibits the detection of infected cells by killer T cells and acts with high efficiency in humans, but poorly, if at all in mouse cells. Here, we show that ICP47 retains modest but detectable function in mouse cells, but in an

Indexed as

Herpes SimplexImmediate-Early ProteinsSimplexvirusAnimalsImmune EvasionMicePromoter Regions, GeneticViral ProteinsVirus LatencyICP47 protein, Herpes simplex virusImmediate-Early ProteinsViral Proteinsherpes simplex virusICP47immune evasionlatencymouse model

Identifiers

PMID37902400
PMCPMC10688380
OpenAlexW4388013860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.