Evidence map›Paper›PMID 37902365›Full record

ArticleBiomaterials science2023

Fluorescent liposomal nanocarriers for targeted drug delivery in ischemic stroke therapy.

Michael R Arul, Ibtihal Alahmadi, Daylin Gamiotea Turro, Aditya Ruikar, Sama Abdulmalik, Justin T Williams, Basavaraju G Sanganahalli, Bruce T Liang, Rajkumar Verma, Sangamesh G Kumbar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Michael R ArulDepartment of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT, USA. kumbar@uchc.edu.
Ibtihal AlahmadiDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Daylin Gamiotea TurroDepartment of Neurosciences, UConn Health, Farmington, CT, USA. raverma@uchc.edu.
Aditya RuikarDepartment of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT, USA. kumbar@uchc.edu.
Sama AbdulmalikDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Justin T WilliamsDepartment of Neurosciences, UConn Health, Farmington, CT, USA. raverma@uchc.edu.
Basavaraju G SanganahalliDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Bruce T LiangCalhuan Cardiology Centre, UConn Health, Farmington, CT, USA.
Rajkumar VermaDepartment of Neurosciences, UConn Health, Farmington, CT, USA. raverma@uchc.edu.ORCID http://orcid.org/0000-0002-1123-6508
Sangamesh G KumbarDepartment of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT, USA. kumbar@uchc.edu.ORCID http://orcid.org/0000-0001-7672-4783
UConn Health · USUniversity of Connecticut · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Therapeutic implications of purinergic receptor P2X4 in ischemic strokeR01NS125405 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Rajkumar Verma · 2022 to 2026
$2.5M
Biodegradable Matrices for Bone HealingR01EB020640 · NIBIB · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA, YU, XIAOJUN · 2017 to 2020
$1.6M
Polysaccharide putty formulations for tissue regenerationR01EB034202 · NIBIB · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2023 to 2026
$1.5M
Biodegradable Matrices with Structural and Physical Cues for Interface EngineeringR01EB030060 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI NUKAVARAPU, SYAM · 2020 to 2024
$1.4M
Supplement to Support the Acquisition of a High-Precision 3D PrinterR01NS134604 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2024 to 2026
$1.3M
Engineered Matrices with Electrical and Chemical Stimulation for Peripheral Nerve RepairR56NS122753 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA · 2022 to 2022
$410k
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS R01 EB020640NIBIB NIH HHS R01 EB030060NIBIB NIH HHS R01 EB034202NINDS NIH HHS R01 NS125405NINDS NIH HHS R01 NS134604NINDS NIH HHS R56 NS122753
6 · The paper itself

Abstract

Ischemic stroke causes acute CNS injury and long-term disability, with limited treatment options such as surgical clot removal or clot-busting drugs. Neuroprotective therapies are needed to protect vulnerable brain regions. The purinergic receptor P2X4 is activated during stroke and exacerbates post-stroke damage. The chemical compound 5-(3-Bromophenyl)-1,3-dihydro-2

Indexed as

Brain IschemiaIschemic StrokeStrokeAnimalsBrainLiposomesMicePolyethylene GlycolsLiposomesPolyethylene Glycols

Identifiers

PMID37902365
PMCPMC10697427
OpenAlexW4388014272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.