Evidence map›Paper›PMID 37902166›Full record

ArticleMolecular oral microbiology2024

Primed inflammatory response by fibroblast subset is necessary for proper oral and cutaneous wound healing.

Zhaoxu Chen, Rahul Debnath, Ifeoma Chikelu, Jonathan X Zhou, Kang I Ko

Open access · greenAbstract read
In one paragraph

Article in Molecular oral microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. ICAM1Frontiers in immunology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zhaoxu ChenDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-8276-2206
Rahul DebnathDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-5910-3993
Ifeoma ChikeluDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jonathan X ZhouDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kang I KoDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · USCenter for Innovation · US

Funding

Wound healing mechanisms by distinct oral fibroblast populationR01DE030415 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KO, KANG I · 2021 to 2025
$1.9M
The role of NF-kB in mesenchymal stem cells during diabetic wound healingK08DE027129 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KO, KANG I · 2017 to 2021
$521k
NIDCR NIH HHS K08 DE027129NIDCR NIH HHS R01 DE030415
6 · The paper itself

Abstract

Fibroblasts are ubiquitous mesenchymal cells that exhibit considerable molecular and functional heterogeneity. Besides maintaining stromal integrity, oral fibroblast subsets are thought to play an important role in host-microbe interaction during injury repair, which is not well explored in vivo. Here, we characterize a subset of fibroblast lineage labeled by paired-related homeobox-1 promoter activity (Prx1Cre

Indexed as

FibroblastsHomeodomain ProteinsMouth MucosaNF-kappa BSkinWound HealingAnimalsChemokine CCL2Chemokine CXCL1InflammationMacrophagesMiceMice, Inbred C57BLMice, KnockoutToll-Like Receptor 4Chemokine CCL2Chemokine CXCL1Homeodomain ProteinsNF-kappa BToll-Like Receptor 4fibroblastimmunomodulationinflammationPrx1regenerationwound healing

Identifiers

PMID37902166
PMCPMC11058109
OpenAlexW4388014261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.