Evidence map›Paper›PMID 37901842›Full record

ArticleFrontiers in bioengineering and biotechnology2023

Accelerating the in vitro emulation of Alzheimer's disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model.

Eunkyung Clare Ko, Sarah Spitz, Francesca Michela Pramotton, Olivia M Barr, Ciana Xu, Georgios Pavlou, Shun Zhang, Alice Tsai, Anna Maaser-Hecker, Mehdi Jorfi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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  12. Vascular microphysiological systems.Current opinion in hematology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Eunkyung Clare Ko *Department of Mechanical Engineering and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Sarah Spitz *Department of Mechanical Engineering and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Francesca Michela PramottonDepartment of Mechanical Engineering and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Olivia M BarrGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Ciana XuGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Georgios PavlouDepartment of Mechanical Engineering and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Shun ZhangDepartment of Mechanical Engineering and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Alice TsaiGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Anna Maaser-HeckerGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Mehdi JorfiGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Se Hoon ChoiGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Rudolph E TanziGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Roger D KammDepartment of Mechanical Engineering and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Massachusetts General Hospital · USMassachusetts Institute of Technology · US

Funding

Human 3D Neuro-Vascular Interaction and Meningeal Lymphatic Models with Application to Alzheimer’s DiseaseR01NS121078 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHOI, SE HOON, JORFI, MEHDI · 2021 to 2025
$2.6M
NINDS NIH HHS R01 NS121078
6 · The paper itself

Abstract

High failure rates in clinical trials for neurodegenerative disorders such as Alzheimer's disease have been linked to an insufficient predictive validity of current animal-based disease models. This has created an increasing demand for alternative, human-based models capable of emulating key pathological phenotypes

Indexed as

Alzheimer’s disease (AD)blood-brain barrier (BBB)microfluidicsmicrophysiological system (MPS)neurospheres

Identifiers

PMID37901842
PMCPMC10600382
OpenAlexW4387461109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.