Evidence map›Paper›PMID 37901832›Full record

ArticleFrontiers in microbiology2023

Interaction between intratumoral microbiota and tumor mediates the response of neoadjuvant therapy for rectal cancer.

Lejia Sun, Jiangming Qu, Xindi Ke, Yue Zhang, Hengyi Xu, Ning Lv, Jingze Leng, Yanbin Zhang, Ai Guan, Yifei Feng and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  4. Microbiota in cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
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  12. A pilot study of gut mucosal and faecal microbiota in rectal cancer: associations with histological response and adverse events following preoperative chemoradiotherapy.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Lejia SunDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jiangming QuChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Xindi KeChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yue ZhangDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hengyi XuChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Ning LvChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Jingze LengSchool of Medicine, Tsinghua University, Beijing, China.
Yanbin ZhangDepartment of Spine Surgery, Beijing Jishuitan Hospital, Beijing, China.
Ai GuanChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yifei FengDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yueming SunDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing Jishuitan Hospital · CNNanjing Medical University · CNPeking Union Medical College Hospital · CNJiangsu Province Hospital · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous observations have demonstrated that the response to neoadjuvant chemoradiotherapy (nCRT) is highly variable in patients with locally advanced rectal cancer (LARC). Recent studies focusing on the intratumoral microbiota of colorectal cancer have revealed its role in oncogenesis and tumor progression. However, limited research has focused on the influence of intratumoral microbiota on the nCRT of LARC. Methods: We explored the microbial profiles in the tumor microenvironment of LARC using RNA-seq data from a published European cohort. Microbial signatures were characterized in pathological complete response (pCR) and non-pCR groups. Multi-omics analysis was performed between intratumor microbiomes and transcriptomes. Results: Microbial α and β diversity were significantly different in pCR and non-pCR groups. Twelve differential microbes were discovered between the pCR and non-pCR groups, six of which were related to subclusters of cancer-associated fibroblasts (CAFs) associated with extracellular matrix formation. A microbial risk score based on the relative abundance of seven differential microbes had predictive value for the nCRT response (AUC = 0.820, Conclusion: Our study presents intratumoral microbes as potential independent predictive markers for the response of nCRT to LARC and demonstrates the underlying mechanism by which the interaction between intratumoral microbes and CAFs mediates the response to nCRT.

Indexed as

biomarkercancer-associated fibroblastsintratumoral microbiotalocally advanced rectal cancerneoadjuvant chemoradiotherapy

Identifiers

PMID37901832
PMCPMC10602640
OpenAlexW4387570250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.