Evidence map›Paper›PMID 37901701›Full record

ArticleGlomerular diseases

Developing an Edema Clinician-Reported Outcome Measure for Nephrotic Syndrome.

Debbie S Gipson, Maisha Pal, Hailey Desmond, Charles Anderson, Liron Walsh, Howard Trachtman, Susan F Massengill, Patrick Gipson, Panduranga S Rao, Joshua Thurman and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glomerular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 3 countries.

Debbie S GipsonDepartment of Pediatrics/Pediatric Nephrology, University of Michigan, Ann Arbor, MI, USA.
Maisha PalDepartment of Pediatrics/Pediatric Nephrology, University of Michigan, Ann Arbor, MI, USA.
Hailey DesmondDepartment of Pediatrics/Pediatric Nephrology, University of Michigan, Ann Arbor, MI, USA.
Charles AndersonDepartment of Pediatrics/Pediatric Nephrology, Levine Children's Hospital at Atrium Health, Charlotte, NC, USA.
Liron WalshGoldfinch Bio, Boston, MA, USA.
Howard TrachtmanDepartment of Pediatrics/Pediatric Nephrology, University of Michigan, Ann Arbor, MI, USA.
Susan F MassengillDepartment of Pediatrics/Pediatric Nephrology, Levine Children's Hospital at Atrium Health, Charlotte, NC, USA.
Patrick GipsonDepartment of Pediatrics/Pediatric Nephrology, University of Michigan, Ann Arbor, MI, USA.
Panduranga S RaoDepartment of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, USA.
Joshua ThurmanDepartment of Internal Medicine/Nephrology, University of Colorado, Aurora, CO, USA.
Jeffrey KoppNational Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Disease, Bethesda, MD, USA.
Elaine KamilDepartment of Pediatrics, Cedars-Sinai Medical Center and the David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jennifer LamotheDepartment of Pediatrics/Pediatric Nephrology, Levine Children's Hospital at Atrium Health, Charlotte, NC, USA.
Laura H MarianiDepartment of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, USA.
Paula LaFleurSt. Clair Nephrology Research, Roseville, MI, USA.
Suzanne VentoGoldfinch Bio, Boston, MA, USA.
Michelle O'ShaughnessyDepartment of Renal Medicine, Cork University Hospital, Cork, Ireland.
Youssef M K FaragGoldfinch Bio, Boston, MA, USA.
Christine SimonDepartment of Pediatrics/Pediatric Nephrology, University of Michigan, Ann Arbor, MI, USA.
Noelle E CarlozziDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · USGoldfinch Bio (United States) · USLevine Children's Hospital · USCedars-Sinai Medical Center · USCork University Hospital · IENational Institute of Diabetes and Digestive and Kidney Diseases · USSt. Clair College · CAUniversity of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Edema is a common manifestation of proteinuric kidney diseases, but there is no consensus approach for reliably evaluating edema. The objective of this study was to develop an edema clinician-reported outcome measure for use in patients with nephrotic syndrome. Methods: A literature review was conducted to assess existing clinician-rated measures of edema. Clinical experts were recruited from internal medicine, nephrology, and pediatric nephrology practices to participate in concept elicitation using semi-structured interviews and cognitive debriefing. Qualitative analysis methods were used to collate expert input and inform measurement development. In addition, training and assessment modules were developed using an iterative process that also utilized expert input and cognitive debriefing to ensure interrater reliability. Results: While several clinician-rated measures of edema have been proposed, our literature review did not identify any studies to support the reliability or validity of these measures. Fourteen clinician experts participated in the concept elicitation interviews, and twelve participated in cognitive debriefing. A clinician-reported outcome measure for edema was developed. The measure assesses edema severity in multiple individual body parts. An online training module and assessment tool were generated and refined using additional clinician input and investigative team expertise. Conclusion: The Edema ClinRO (V1) measure is developed specifically to measure edema in nephrotic syndrome. The tool assesses edema across multiple body parts, and it includes a training module to ensure standardized administration across raters. Future examination of this measure is ongoing to establish its reliability and validity.

Indexed as

Clinical outcomes assessmentClinROFocal segmental glomerulosclerosisMembranous nephropathyMinimal change diseaseSwelling

Identifiers

PMID37901701
PMCPMC10601938
OpenAlexW4385668579

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.