Evidence map›Paper›PMID 37901602›Full record

ArticleFrontiers in epigenetics and epigenomics2023

Targeted RNAi screen identifies transcriptional mechanisms that prevent premature degeneration of adult photoreceptors.

Spencer E Escobedo, Sarah E McGovern, Juan P Jauregui-Lozano, Sarah C Stanhope, Paul Anik, Kratika Singhal, Ryan DeBernardis, Vikki M Weake

Open access · diamondAbstract read
In one paragraph

Article in Frontiers in epigenetics and epigenomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Spencer E EscobedoDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Sarah E McGovernDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Juan P Jauregui-LozanoDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Sarah C StanhopeDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Paul AnikDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Kratika SinghalDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Ryan DeBernardisDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Vikki M WeakeDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Purdue University West Lafayette · USCenter for Cancer Research · US

Funding

Epigenetic Regulation of Gene Expression in the Aging EyeR01EY024905 · NEI · PURDUE UNIVERSITY · PI WEAKE, VIKKI MARIE · 2015 to 2020
$2.3M
Chromatin connects metabolism to circadian gene regulation in the aging eyeR01EY033734 · NEI · PURDUE UNIVERSITY · PI Vikki Marie Weake · 2023 to 2026
$1.5M
Purdue Drug Discovery Training ProgramT32GM125620 · NIGMS · PURDUE UNIVERSITY · PI DYKHUIZEN, EMILY CARLA, WEI, ALEXANDER · 2019 to 2023
$891k
NEI NIH HHS R01 EY024905NEI NIH HHS R01 EY033734NIGMS NIH HHS T32 GM125620
6 · The paper itself

Abstract

Aging is associated with a decline in visual function and increased prevalence of ocular disease, correlating with changes in the transcriptome and epigenome of cells in the eye. Here, we sought to identify the transcriptional mechanisms that are necessary to maintain photoreceptor viability and function during aging. To do this, we performed a targeted photoreceptor-specific RNAi screen in

Indexed as

agingDrosophilaepigeneticeyephotoreceptorsretinal degenerationRNAi screen

Identifiers

PMID37901602
PMCPMC10603763
OpenAlexW4381468693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.