Evidence map›Paper›PMID 37901442›Full record

ArticlePNAS nexus2023

A biomimetic chip to assess subcutaneous bioavailability of monoclonal antibodies in humans.

Vineeth Chandran Suja, Qin M Qi, Kevin Halloran, Jifeng Zhang, Suyog Shaha, Supriya Prakash, Ninad Kumbhojkar, Antoine Deslandes, Sylvain Huille, Yatin R Gokarn and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Vineeth Chandran SujaSchool of Engineering and Applied Sciences, Harvard University, Boston, MA 02134, USA.
Qin M QiSchool of Engineering and Applied Sciences, Harvard University, Boston, MA 02134, USA.
Kevin HalloranSanofi, 350 Water St, Cambridge, MA 02141, USA.
Jifeng ZhangSanofi, 350 Water St, Cambridge, MA 02141, USA.
Suyog ShahaSchool of Engineering and Applied Sciences, Harvard University, Boston, MA 02134, USA.
Supriya PrakashSchool of Engineering and Applied Sciences, Harvard University, Boston, MA 02134, USA.
Ninad KumbhojkarSchool of Engineering and Applied Sciences, Harvard University, Boston, MA 02134, USA.
Antoine DeslandesSanofi R&D, Impasse Des Ateliers, Vitry-sur-Seine 94400 France.
Sylvain HuilleSanofi R&D, Impasse Des Ateliers, Vitry-sur-Seine 94400 France.
Yatin R GokarnSanofi, 350 Water St, Cambridge, MA 02141, USA.
Samir MitragotriSchool of Engineering and Applied Sciences, Harvard University, Boston, MA 02134, USA.
Harvard University · USSanofi (United States) · USSanofi (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subcutaneous (subQ) injection is a common route for delivering biotherapeutics, wherein pharmacokinetics is largely influenced by drug transport in a complex subQ tissue microenvironment. The selection of good drug candidates with beneficial pharmacokinetics for subQ injections is currently limited by a lack of reliable testing models. To address this limitation, we report here a

Identifiers

PMID37901442
PMCPMC10612570
OpenAlexW4387460824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.