ArticleFrontiers in neuroscience2023
Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Chiropractic Care Is Associated with Frequency-Specific Reorganisation of Triple-Network Brain Dynamics: A Source-Localised EEG Study.Brain sciences · 2026Article
- Breathing-Controlled Electrical Stimulation (BreEStim) Selectively Modulates Affective and Cognitive Components of Pain-An EEG Study.Bioengineering (Basel, Switzerland) · 2026Article
- Transcranial Alternating Current Stimulation for Pain: Mixed Evidence and the Path to Precision Neuromodulation.Brain sciences · 2026Review
- The moderating role of trait mindfulness on pain perception: insights from pain-related electroencephalography oscillations.Pain reports · 2025Article
- EEG oscillations reveal neuroplastic changes in pain processing associated with long-term meditation.Scientific reports · 2025Article
- Pain and the Brain: A Systematic Review of Methods, EEG Biomarkers, Limitations, and Future Directions.Neurology international · 2025Review
- Disruptions in cortical circuit connectivity distinguish widespread hyperalgesia from localized pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- EEG alpha/beta features as a biomarker for quantifying pain in patients with lumbar disk herniation.Frontiers in neuroscience · 2025Article
- Neuromuscular characteristics of transcranial direct current stimulation over dorsolateral prefrontal cortex in patients with chronic low back pain: a randomized, double-blind, controlled trial protocol.Frontiers in human neuroscience · 2025Article
- Decoding pain's neural rhythm: Gamma oscillation mechanisms, therapeutic modulation, and translational challenges in pain management.Frontiers in neuroscience · 2025Review
- Imbalance in positive and negative acceleration ratio of alpha oscillation in patients with complex regional pain syndrome.Heliyon · 2024Article
- The psychophysiology of music-based interventions and the experience of pain.Frontiers in psychology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Chronic pain negatively impacts a range of sensory and affective behaviors. Previous studies have shown that the presence of chronic pain not only causes hypersensitivity at the site of injury but may also be associated with pain-aversive experiences at anatomically unrelated sites. While animal studies have indicated that the cingulate and prefrontal cortices are involved in this generalized hyperalgesia, the mechanisms distinguishing increased sensitivity at the site of injury from a generalized site-nonspecific enhancement in the aversive response to nociceptive inputs are not well known. Methods: We compared measured pain responses to peripheral mechanical stimuli applied to a site of chronic pain and at a pain-free site in participants suffering from chronic lower back pain ( Results: As expected, participants with chronic pain endorsed enhanced pain with mechanical stimuli in both back and hand. We further analyzed electroencephalographic (EEG) recordings during these evoked pain episodes. Brain oscillations in theta and alpha bands in the medial orbitofrontal cortex (mOFC) were associated with localized hypersensitivity, while increased gamma oscillations in the anterior cingulate cortex (ACC) and increased theta oscillations in the dorsolateral prefrontal cortex (dlPFC) were associated with generalized hyperalgesia. Discussion: These findings indicate that chronic pain may disrupt multiple cortical circuits to impact nociceptive processing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.