Evidence map›Paper›PMID 37901429›Full record

ArticleFrontiers in neuroscience2023

Simone R Williams, Frances C Robertson, Catherine J Wedderburn, Jessica E Ringshaw, Layla Bradford, Charmaine N Nyakonda, Nadia Hoffman, Shantanu H Joshi, Heather J Zar, Dan J Stein and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Simone R WilliamsDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Frances C RobertsonDepartment of Human Biology, University of Cape Town, Cape Town, South Africa.
Catherine J WedderburnDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Jessica E RingshawDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Layla BradfordDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Charmaine N NyakondaDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Nadia HoffmanDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Shantanu H JoshiDepartments of Neurology and Bioengineering, UCLA, University of California, Los Angeles, Los Angeles, CA, United States.
Heather J ZarDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Dan J SteinNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Kirsten A DonaldDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Red Cross War Memorial Children's Hospital · ZAUniversity of Cape Town · ZASouth African Medical Research Council · ZAUniversity of California, Los Angeles · US

Funding

Cross-Cultural Assessment of FASDU24AA014811 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY · 2003 to 2026
$13.1M
Tracking and Prediction of Early Brain-Face Biomarkers of Prenatal Alcohol Exposure from Neonates to ChildrenR01AA026834 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kirsty Donald, Shantanu H. Joshi · 2018 to 2026
$3.8M
A neuroimaging study of 2 year old children with alcohol exposure compared to healthy unexposed controls embedded in a birth cohort studyR21AA023887 · NIAAA · UNIVERSITY OF CAPE TOWN · PI DONALD, KIRSTY · 2016 to 2017
$280k
NIAAA NIH HHS R01 AA026834NIAAA NIH HHS R21 AA023887NIAAA NIH HHS U24 AA014811
6 · The paper itself

Abstract

Objective: Alterations in regional neurometabolite levels as well as impaired neurodevelopmental outcomes have previously been observed in children who are HIV-exposed uninfected (CHEU). However, little is known about how neurometabolite profiles may relate to their developmental impairment. This study aimed to compare neurometabolite concentrations in school-aged CHEU and children who are HIV-unexposed (CHU) and to explore associations of neurometabolite profiles with functional neurodevelopment in the context of perinatal HIV exposure. Methods: We used 3 T single voxel proton magnetic resonance spectroscopy ( Results: Our study included 152 school-aged children (50% males), 110 CHEU and 42 CHU, with an average age of 74 months at the neuroimaging visit. In an adjusted multiple linear regression analysis, significantly lower glutamate (Glu) concentrations were found in CHEU as compared to CHU in the parietal gray matter (absolute Glu, Conclusion: Reduced Glu concentrations in the parietal gray matter may suggest regional alterations in excitatory glutamatergic transmission pathways in the context of perinatal HIV and/or antiretroviral therapy (ART) exposure, while reduced Cho ratios in the parietal white matter suggest regional myelin loss. Identified associations between neurometabolite profiles and gross and fine motor developmental outcomes in CHEU are suggestive of a neurometabolic mechanism that may underlie impaired motor neurodevelopmental outcomes observed in CHEU.

Indexed as

brain developmentHIV exposuremagnetic resonance spectroscopymetabolitesneuroimaging

Identifiers

PMID37901429
PMCPMC10600451
OpenAlexW4387576061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.