Evidence map›Paper›PMID 37901347›Full record

ArticleJournal of immunology research2023

The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study.

Bente M Houtman, Iris Walraven, Elke de Grouw, Richard W M van der Maazen, Leontien C M Kremer, Eline van Dulmen-den Broeder, Marry M van den Heuvel-Eibrink, Wim J E Tissing, Dorine Bresters, Helena J H van der Pal and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Bente M HoutmanDepartment of Hematology, Center of Expertise for Cancer Survivorship, Radboud University Medical Center, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0002-9242-5676
Iris WalravenDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, Netherlands.
Elke de GrouwDepartment of Laboratory Medicine-Radboudumc Laboratory of Diagnostics, Radboud University Medical Center, Nijmegen, Netherlands.
Richard W M van der MaazenDepartment of Radiotherapy, Radboud University Medical Center, Nijmegen, Netherlands.
Leontien C M KremerPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Eline van Dulmen-den BroederDepartment of Pediatric Oncology/Hematology, Amsterdam University Medical Center, Amsterdam, Netherlands.
Marry M van den Heuvel-EibrinkPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Wim J E TissingPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Dorine BrestersPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Helena J H van der PalPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Andrica C H de VriesDepartment of Pediatric Oncology, Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, Netherlands.
Marloes LouwerensDepartment of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands.
Margriet van der Heiden-van der LooPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Sebastian J C NeggersPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Geert O JanssensPrincess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Nicole M A BlijlevensDepartment of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.
Annechien J A LambeckDepartment of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands.
Frank PreijersDepartment of Laboratory Medicine-Laboratory for Hematology, Radboud University Medical Center, Nijmegen, Netherlands.
Jacqueline J LoonenDepartment of Hematology, Center of Expertise for Cancer Survivorship, Radboud University Medical Center, Nijmegen, Netherlands.
Radboud University Nijmegen · NLPrincess Máxima Center · NLUniversity Medical Center Utrecht · NLUniversity Medical Center Groningen · NLErasmus MC · NLErasmus MC - Sophia Children’s Hospital · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective: We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the spleen, or TBI. Methods: All CCS were enrolled from the DCCSS-LATER cohort. We analyzed differences in IgM memory B-cells and Howell-Jolly bodies (HJB) in CCS who had a splenectomy ( Results: We observed a higher median number of IgM memory B-cells in CCS who received radiotherapy involving the spleen (31 cells/ Conclusion: Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction.

Indexed as

Cancer SurvivorsNeoplasmsChildHumansImmunoglobulin MSpleenSplenectomyImmunoglobulin M

Identifiers

PMID37901347
PMCPMC10611543
OpenAlexW4387823090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.