Evidence map›Paper›PMID 37901221›Full record

ArticleFrontiers in immunology2023

An optimized cocktail of small molecule inhibitors promotes the maturation of dendritic cells in GM-CSF mouse bone marrow culture.

Shintaro Matsuba, Hiroki Ura, Fumiji Saito, Chie Ogasawara, Shigetaka Shimodaira, Yo Niida, Nobuyuki Onai

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shintaro MatsubaDepartment of Immunology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Hiroki UraCenter for Clinical Genomics, Kanazawa Medical University Hospital, Uchinada, Ishikawa, Japan.
Fumiji SaitoDepartment of Immunology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Chie OgasawaraDepartment of Immunology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Shigetaka ShimodairaDepartment of Regenerative Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Yo NiidaCenter for Clinical Genomics, Kanazawa Medical University Hospital, Uchinada, Ishikawa, Japan.
Nobuyuki OnaiDepartment of Immunology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Kanazawa Medical University · JPKanazawa Medical University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are the most potent antigen-presenting cells, playing an essential role in the pathogen and tumor recognition, and anti-tumor immunity, and linking both the innate and adaptive immunity. The monocyte-derived DCs generated by ex vivo culture, have been used for cancer immunotherapy to eliminate tumor; however, the clinical efficacies are not sufficient, and further improvement is essential. In this study, we established a method to generate DCs using small molecule compounds for cancer immunotherapy. We observed an increase in the percentage of CD11c

Indexed as

Granulocyte-Macrophage Colony-Stimulating FactorNeoplasmsAnimalsBone MarrowDendritic CellsMiceT-LymphocytesGranulocyte-Macrophage Colony-Stimulating Factorcytokine productiondendritic cellsimmunotherapymixed lymphoid reactionsmall molecule inhibitor

Identifiers

PMID37901221
PMCPMC10611476
OpenAlexW4387603211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.