Evidence map›Paper›PMID 37901038›Full record

ArticleBrain communications2023

Correspondence of mean apparent propagator MRI metrics with phosphorylated tau and astrogliosis in chronic traumatic encephalopathy.

Mihika Gangolli, Sinisa Pajevic, Joong Hee Kim, Elizabeth B Hutchinson, Dan Benjamini, Peter J Basser

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mihika GangolliCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20817, USA.ORCID https://orcid.org/0000-0002-8764-4313
Sinisa PajevicSection on Critical Brain Dynamics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
Joong Hee KimCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20817, USA.
Elizabeth B HutchinsonSection on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Dan BenjaminiCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20817, USA.
Peter J BasserCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20817, USA.
National Institutes of Health · USHenry M. Jackson Foundation · US

Funding

CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo ImagingU01NS086659 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2014 to 2017
$6.1M
Imaging Water Diffusion in the Brain and in Other Soft TissuesZIAHD000266 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BASSER, PETER J. · 2009 to 2017
$3.3M
Intramural NIH HHS ZIA HD000266NINDS NIH HHS U01 NS086659
6 · The paper itself

Abstract

Chronic traumatic encephalopathy is a neurodegenerative disease that is diagnosed and staged based on the localization and extent of phosphorylated tau pathology. Although its identification remains the primary diagnostic criteria to distinguish chronic traumatic encephalopathy from other tauopathies, the hyperphosphorylated tau that accumulates in neurofibrillary tangles in cortical grey matter and perivascular regions is often accompanied by concomitant pathology such as astrogliosis. Mean apparent propagator MRI is a clinically feasible diffusion MRI method that is suitable to characterize microstructure of complex biological media efficiently and comprehensively. We performed quantitative correlations between propagator metrics and underlying phosphorylated tau and astroglial pathology in a cross-sectional study of 10

Indexed as

chronic traumatic encephalopathydiffusion imagingk-means clusteringMAP-MRIphosphorylated tau

Identifiers

PMID37901038
PMCPMC10600571
OpenAlexW4387358076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.