ArticleFrontiers in cardiovascular medicine2023
Relative importance of left atrial reservoir strain compared with components of the HFA-PEFF score: a cross-sectional study.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05638230 (Relative Importance of Cardiovascular Risk Factors and Echocardiographic Parameters Affecting Left Atrial Strain), which is not on this map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relative Importance of Cardiovascular Risk Factors and Echocardiographic Parameters Affecting Left Atrial Strain
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Evaluation of diastolic function: machine learning improves classification of left ventricular filling pressure.European heart journal. Cardiovascular Imaging · 2026Article
- Left atrial reservoir strain as a predictor for left ventricular filling pressure in patients with sinus rhythm.Scientific reports · 2025Article
- Three-Dimensional Left Atrial Reservoir Function During Sinus Rhythm Can Discriminate Between a History of Paroxysmal Atrial Fibrillation and its Absence.Clinical Medicine Insights. Cardiology · 2025Article
- ESC Congress 2022 Imaging Highlights.European cardiology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relative importance of left atrial reservoir strain (LASr) regarding the Heart Failure Association Pre-test assessment, Echocardiography and natriuretic peptide, Functional testing, Final etiology (HFA-PEFF) score, a diagnostic tool for patients with heart failure with preserved ejection fraction (HFpEF), remains unclear. We aimed to identify the relative importance of LASr compared with variables associated with HFpEF and HFA-PEFF scores. Methods: Between August 2021 and July 2022, we obtained retrospective data from the participants visiting a single cardiovascular center with subjective symptoms of heart failure, such as dyspnea or chest discomfort. In total, 2,712 participants with sinus rhythm and ejection fraction of more than 50% were enrolled. Multivariable logistic regression analysis, random forest analysis, and supervised machine learning algorithms were performed to identify the relative importance of LASr to the HFA-PEFF score. Results: The average HFA-PEFF score was 2.4 ± 1.6 points. Two hundred and thirty-eight participants had 5 or 6 points. LASr showed a moderate correlation with the HFA-PEFF score (r = -0.50, Conclusions: LASr is an important factor with components of the HFA-PEFF score and is a useful tool to assess patients with HFpEF. Clinical Trial Registration: URL: https://clinicaltrials.org. Unique identifiers: NCT05638230.
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