ArticleWorld journal of clinical cases2023
Prognostic model of hepatocellular carcinoma based on cancer grade.
Article in World journal of clinical cases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC.Scientific reports · 2025Article
- Stage-dependent EZH2 methylation correlates with immune polarization, metabolic suppression, and unfavorable outcomes in hepatocellular carcinoma.International journal of medical sciences · 2025Article
- Omics-imaging signature-based nomogram to predict the progression-free survival of patients with hepatocellular carcinoma after transcatheter arterial chemoembolization.World journal of clinical cases · 2024Article
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Authors and funding
3 authors.
Funding
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Abstract
backgroundHepatocellular carcinoma (HCC) is the most common type of primary liver cancer. With highly invasive biological characteristics and a lack of obvious clinical manifestations, HCC usually has a poor prognosis and ranks fourth in cancer mortality. The aetiology and exact molecular mechanism of primary HCC are still unclear.
aimTo select the characteristic genes that are significantly associated with the prognosis of HCC patients and construct a prognosis model of this malignancy.
methodsBy comparing the gene expression levels of patients with different cancer grades of HCC, we screened out differentially expressed genes associated with tumour grade. By protein-protein interaction (PPI) network analysis, we obtained the top 2 PPI networks and hub genes from these differentially expressed genes. By using least absolute shrinkage and selection operator Cox regression, 13 prognostic genes were selected for feature extraction, and a prognostic risk model of HCC was established.
resultsThe model had significant prognostic ability in HCC. We also analysed the biological functions of these prognostic genes.
conclusionBy comparing the gene profiles of patients with different stages of HCC, We have constructed a prognosis model consisting of 13 genes that have important prognostic value. This model has good application value and can be explained clinically.
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