ArticleFrontiers in endocrinology2023
Elevated serum creatinine levels and risk of cognitive impairment in older adults with diabetes: a NHANES study from 2011-2014.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 20 citations in OpenAlex.
- Interpretable machine learning for cognitive impairment assessment: integration of clinical and radiomic white matter hyperintensities features.Journal of translational medicine · 2026Article
- A Machine Learning and Traditional Chinese Medicine Constitution-Based Prediction Model for Mild Cognitive Impairment in Community-Dwelling Older Adults.Neuropsychiatric disease and treatment · 2026Article
- Serum copper modulates cognitive function in diabetic patients via an HDL-C-mediated pathway: identification of a 25 µg/dL exploratory threshold.Diabetology & metabolic syndrome · 2025Article
- Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- A review of type 2 diabetes mellitus and cognitive impairment.Frontiers in endocrinology · 2025Review
- Five-year dementia prediction and decision support system based on real-world data.Frontiers in aging neuroscience · 2025Article
- Study on influencing factors of age-adjusted Charlson comorbidity index in patients with Alzheimer's disease based on machine learning model.Frontiers in medicine · 2025Article
- Diabetic retinopathy as the primary predictor of mild cognitive impairment in type 2 diabetes: Insights from machine learning models.PloS one · 2025Article
- Development and validation of a nomogram of all-cause mortality in adult Americans with diabetes.Scientific reports · 2024Article
- Global, regional, and national burden inequality of chronic kidney disease, 1990-2021: a systematic analysis for the global burden of disease study 2021.Frontiers in medicine · 2024Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
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Abstract
Background: The brain and kidney have similar microvascular structure, which makes them susceptible to certain common pathophysiological processes. In this study, we examined several indicators of kidney injury/function associated with cognitive function in older diabetic patients in the hope of finding effective markers for detecting cognitive impairment (CI). Methods: A total of 2209 older participants (aged ≥60 years) from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) were analyzed for the association between diabetes and CI using a multiple linear regression analysis model. Using the same approach, we also analyzed the relationship between indicators of kidney injury/function and cognitive function (Animal Fluency Test, Digit Symbol Substitution Test) in the diabetic population. Results: Diabetes was associated with CI. In age-adjusted model, older diabetics performed significantly poorer on tests of cognitive function compared to normoglycaemic individuals (1.145 points lower on the Animal Fluency Test ( Conclusion: SCr, as a sensitive indicator of kidney injury, was significantly associated with CI and can potentially be used as an effective marker for screening CI in older diabetics.
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