ArticleFrontiers in endocrinology2023
Association between sarcopenia-related traits and cardiovascular diseases: a bi-directional Mendelian randomization study.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Optimal dose of resistance training to improve handgrip strength in older adults with sarcopenia: a systematic review and Bayesian model-based network meta-analysis.Frontiers in physiology · 2025Pooled it
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Association between cognitive function and all-cause mortality among US older adults with cardiovascular-kidney-metabolic syndrome.BMC geriatrics · 2026Article
- Combined and progressive effect of frailty and sarcopenia on the risk of cardiovascular disease in middle-aged and older adults.Journal of global health · 2025Article
- Sarcopenia (defined by low muscle mass) as a predictor of disease progression and mortality in cardiovascular-kidney-metabolic syndrome.Diabetology & metabolic syndrome · 2025Article
- Changes in Sarcopenia Status and Subsequent Cardiovascular Outcomes: Prospective Cohort Study.JMIR aging · 2025Observational
- Associations of Sarcopenia and Its Components With Cardiovascular Risk: Five-Year Longitudinal Evidence From China Health and Retirement Longitudinal Study.Journal of the American Heart Association · 2025Article
- Occurrence of sarcopenia in elderly patients with coronary heart disease and its association with short-term prognosis.BMC cardiovascular disorders · 2025Article
- Prognostic implication of sarcopenia diagnosed by updated Asian Working Group for Sarcopenia criteria in older patients with heart failure: Utility and limitation.The journal of nutrition, health & aging · 2025Article
- Individual and joint association of Life's Essential 8 metrics with pre-sarcopenia among U.S. adults.BMC musculoskeletal disorders · 2024Article
- Association between relative muscle strength and cardiovascular disease among middle-aged and older adults in China.BMC public health · 2024Article
- Targeting cardiac and cerebrovascular risks of sarcopenia: Is it time to screen for muscle health?Journal of the American Geriatrics Society · 2024Article
- Osteoporosis and coronary heart disease: a bi-directional Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Hand grip strength and all-cause mortality risk in individuals with decreased bone mass: a study from NHANES database.Frontiers in medicine · 2024Article
- Current approach to the diagnosis of sarcopenia in cardiovascular diseases.Frontiers in nutrition · 2024Review
- Mendelian randomization analysis reveals no causal relationship between thyroid function and sarcopenia-related traits.Frontiers in endocrinology · 2024Article
- Association of atherogenic index of plasma and triglyceride glucose-body mass index and sarcopenia in adults from 20 to 59: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Additive impact of metabolic syndrome and sarcopenia on all-cause and cause-specific mortality: an analysis of NHANES.Frontiers in endocrinology · 2024Article
- Systemic immune-inflammation index and all-cause and cause-specific mortality in sarcopenia: a study from National Health and Nutrition Examination Survey 1999-2018.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The two geriatric diseases, sarcopenia and cardiovascular disease (CVD), often coexist, yet the causal relationship is unclear. However, few studies focus on the effect of muscle mass on CVD. This comprehensive study is dedicated to unearthing the potential connection between sarcopenia-related traits and CVD at the genetic level. Method: A two-sample bi-directional Mendelian randomization (MR) study was conducted. In the first stage, we performed MR analysis regarding coronary heart disease (CHD), stroke, and myocardial infarction (MI) as exposure factors to reveal their effect on appendicular lean mass (ALM) and hand grip strength. In the second stage, we reverse the position of exposures and outcomes. The inverse variance weighted (IVW) method was used as the primary approach to reveal the potential causation between the exposure and outcome. Results: The results of the IVW method revealed a negative causal effect of ALM on CHD (OR = 0.848, 95% CI = 0.804 to 0.894, p = 8.200E-10), stroke (OR = 0.931, 95% CI = 0.890 to 0.975, p = 2.220E-03), and MI (OR = 0.810, 95% CI = 0.694 to 0.901, p = 1.266E-13). Additionally, the left-hand grip strength is a significant protective factor for CHD (OR = 0.737, 95% CI = 0.601 to 0.904, p = 3.353E-03) and MI (OR = 0.631, 95% CI = 0.515 to 0.765, p = 2.575E-06), but is not causally linked to the stroke (OR = 0.971, 95% CI =0.829 to 1.139, p = 0.720). Meanwhile, the same conclusion about the effect of right-hand grip strength on CHD (OR = 0.681, 95% CI = 0.558 to 0.832, p = 1.702E-05), MI (OR = 0.634, 95% CI = 0.518 to 0.776, p = 9.069E-06), and stroke (OR = 1.041, 95% CI = 0.896 to 1.209, p = 0.604) was obtained. However, no significant causal effect of CVD (CHD, stroke, MI) on sarcopenia-related traits (ALM, handgrip strength) was found. Conclusion: There is a unidirectional causal relationship between sarcopenia and CVD. The loss of muscle mass and strength has a significant causal role in promoting the occurrence and development of CVD, providing a reference for the prevention and treatment of comorbidities in older people.
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