Evidence map›Paper›PMID 37900026›Full record

ArticleFrontiers in public health2023

HIV test-and-treat policy improves clinical outcomes in Zambian adults from Southern Province: a multicenter retrospective cohort study.

Benson M Hamooya, Simon Mutembo, Brian Muyunda, Keith Mweebo, Nzali Kancheya, Lyapa Sikazwe, Morgan Sakala, Johanzi Mvula, Salazeh Kunda, Shem Kabesha and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Benson M HamooyaSchool of Medicine and Health Sciences, Mulungushi University, Livingstone, Zambia.
Simon MutemboInternational Vaccine Access Center, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Brian MuyundaCenters for Disease Control and Prevention, Lusaka, Zambia.
Keith MweeboCenters for Disease Control and Prevention, Lusaka, Zambia.
Nzali KancheyaCenters for Disease Control and Prevention, Lusaka, Zambia.
Lyapa SikazweProvincial Medical Office, Ministry of Health, Choma, Zambia.
Morgan SakalaProvincial Medical Office, Ministry of Health, Choma, Zambia.
Johanzi MvulaProvincial Medical Office, Ministry of Health, Choma, Zambia.
Salazeh KundaProvincial Medical Office, Ministry of Health, Choma, Zambia.
Shem KabeshaProvincial Medical Office, Ministry of Health, Choma, Zambia.
Chilala CheeloSchool of Medicine and Health Sciences, Mulungushi University, Livingstone, Zambia.
Isaac FwembaSchool of Public Health, University of Zambia, Lusaka, Zambia.
Clive BandaProvincial Medical Office, Ministry of Health, Choma, Zambia.
Sepiso K MasengaSchool of Medicine and Health Sciences, Mulungushi University, Livingstone, Zambia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Globally, most countries have implemented a test-and-treat policy to reduce morbidity and mortality associated with HIV infection. However, the impact of this strategy has not been critically appraised in many settings, including Zambia. We evaluated the retention and clinical outcomes of adults enrolled in antiretroviral therapy (ART) and assessed the impact of the test-and-treat policy. Methods: We conducted a retrospective cohort study among 6,640 individuals who initiated ART between January 1, 2014 and July 31, 2016 [before test-and-treat cohort (BTT), Results: The median age [interquartile range (IQR)] was 34.8 years (28.0, 42.1), and 60.2% ( Conclusion: The retention rate and attrition factors improved in the ATT compared to the BTT cohorts. Drivers of retention were test-and-treat policy, older age, high BMI, rural residence, marital status, and WHO stage 1. Therefore, there is need for interventions targeting young people, urban residents, non-married people, and those in the symptomatic WHO stages and with low BMI. Our findings highlight improved ART retention after the implementation of the test-and-treat policy.

Indexed as

Anti-HIV AgentsHIV InfectionsAdultFemaleHumansMalePolicyRetrospective StudiesZambiaAnti-HIV Agentsantiretroviral therapyclinical outcomesHIVretentionSouthern Provincetest-and-treattestingZambia

Identifiers

PMID37900026
PMCPMC10600392

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.